Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, 210009, China.
Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, 210009, China.
Chemosphere. 2024 Aug;361:141485. doi: 10.1016/j.chemosphere.2024.141485. Epub 2024 Mar 4.
Evidence on the association of volatile organic compounds (VOCs) with chronic bronchitis (CB) and emphysema is spare and defective. To evaluate the relationship between urinary metabolites of VOCs (mVOCs) with CB and emphysema, and to identify the potential mVOC of paramount importance, data from NHANES 2011-2014 waves were utilized. Logistic regression was conducted to estimate the independent association of mVOCs with respiratory outcomes. Least absolute shrinkage and selection operator (LASSO) regression was performed to screen a parsimonious set of CB- and emphysema-relevant mVOCs that were used for further co-exposure analyses of weighted quantile sum (WQS) regression and Bayesian kernel machine regression (BKMR). Mediation analysis was employed to detect the mediating role of inflammatory makers in such associations. In single exposure analytic model, nine mVOCs were individually and positively associated with CB, while four mVOCs were with emphysema. In WQS regression, positive association between LASSO selected mVOCs and CB was identified (OR = 1.82, 95% CI: 1.25 to 2.69), and N-acetyl-S-(4-hydroxy-2-butenyl)-l-cysteine (MHBMA3) weighted the highest. Results from BKMR further validated such combined association and the significance of MHBMA3. As for emphysema, significantly positive overall trend of mVOCs was only observed in BKMR model and N-acetyl-S-(N-methylcarbamoyl)-l-cysteine (AMCC) contributed most to the mixed effect. White blood cell count (WBC) and lymphocyte number (LYM) were mediators in the positive pattern of mVOCs mixture with CB, while association between mVOCs mixture and emphysema was significantly mediated by LYM and segmented neutrophils num (NEO). This study demonstrated that exposure to VOCs was associated with CB and emphysema independently and combinedly, which might be partly speculated that VOCs were linked to activated inflammations. Our findings shed novel light on VOCs related respiratory illness, and provide a new basis for the contribution of certain VOCs to the risk of CB and emphysema, which has potential public health implications.
有关挥发性有机化合物（VOCs）与慢性支气管炎（CB）和肺气肿之间关联的证据很少且存在缺陷。为了评估尿液中 VOCs 代谢物（mVOCs）与 CB 和肺气肿之间的关系，并确定最重要的潜在 mVOC，利用了 NHANES 2011-2014 年的数据。采用逻辑回归来估计 mVOC 与呼吸结局的独立关联。采用最小绝对收缩和选择算子（LASSO）回归筛选与 CB 和肺气肿相关的简约 mVOC 集，用于进一步进行加权分位数总和（WQS）回归和贝叶斯核机器回归（BKMR）的共暴露分析。采用中介分析来检测炎症标志物在这些关联中的中介作用。在单一暴露分析模型中，有 9 种 mVOC 分别与 CB 呈正相关，而有 4 种 mVOC 与肺气肿呈正相关。在 WQS 回归中，确定了 LASSO 选择的 mVOCs 与 CB 之间存在正相关关系（OR=1.82，95%CI：1.25 至 2.69），N-乙酰-S-（4-羟基-2-丁烯基）-l-半胱氨酸（MHBMA3）的权重最高。BKMR 的结果进一步验证了这种联合关联和 MHBMA3 的重要性。至于肺气肿，仅在 BKMR 模型中观察到 mVOCs 的整体显著正趋势，而 N-乙酰-S-（N-甲基氨基甲酰基）-l-半胱氨酸（AMCC）对混合效应的贡献最大。白细胞计数（WBC）和淋巴细胞计数（LYM）是 mVOCs 混合物与 CB 呈正相关的中介物，而 mVOCs 混合物与肺气肿之间的关联则主要由 LYM 和分段中性粒细胞数（NEO）介导。本研究表明，暴露于 VOCs 与 CB 和肺气肿独立和联合相关，这可能部分推测 VOCs 与激活的炎症有关。我们的研究结果为与 VOCs 相关的呼吸道疾病提供了新的认识，并为某些 VOC 对 CB 和肺气肿风险的贡献提供了新的依据，这具有潜在的公共卫生意义。
