Department of Pulmonary Medicine, Allergology and Clinical Immunology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Division of Internal Medicine, University and Hospital of Fribourg, Fribourg, Switzerland.
BMJ Case Rep. 2024 Mar 29;17(3):e256509. doi: 10.1136/bcr-2023-256509.
Tularaemia is a highly infectious, zoonotic disease caused by , which has become increasingly prevalent over the past decade. Depending on the route of infection, different clinical manifestations can be observed. We report a case of typhoidal tularaemia presenting as a febrile illness with gastrointestinal symptoms in a patient in her mid-80s. During the acute illness phase and in the context of alcohol-related liver cirrhosis, the patient developed progressive ascites. During paracentesis, spontaneous bacterial peritonitis was consistently reported. Blood culture revealed Gram-negative bacilli identified as upon microscopic examination. Immediate clinical improvement was observed after adaptation to a pathogen-specific antibiotic regime. Typhoidal tularaemia presents general, non-specific symptoms without the local manifestations seen in other forms of the disease, thus representing a diagnostic challenge. In the case of protracted fever and if the epidemiological context as well as possible exposure are compatible, tularaemia should be considered in the differential diagnosis.
兔热病是一种由 引起的高度传染性、人畜共患疾病,在过去十年中变得越来越普遍。根据感染途径的不同,可观察到不同的临床表现。我们报告了一例 80 多岁女性患者,表现为发热伴胃肠道症状的伤寒型兔热病。在急性疾病期和与酒精性肝硬化相关的情况下,患者出现进行性腹水。在进行经皮穿刺时,始终报告自发性细菌性腹膜炎。血培养显示革兰氏阴性杆菌,经显微镜检查鉴定为 。在适应针对病原体的抗生素治疗方案后,患者的临床状况立即得到改善。伤寒型兔热病表现为一般性、非特异性症状,没有其他形式疾病中所见的局部表现,因此构成诊断挑战。在长期发热的情况下,如果流行病学背景以及可能的暴露情况相符,应在鉴别诊断中考虑兔热病。