基于数据和理论的方法研究上皮间质转化的路径。
Data- and theory-driven approaches for understanding paths of epithelial-mesenchymal transition.
机构信息
Department of Biochemistry & Cellular and Molecular Biology, The University of Tennessee, Knoxville, Tennessee, USA.
Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
出版信息
Genesis. 2024 Apr;62(2):e23591. doi: 10.1002/dvg.23591.
Reversible transitions between epithelial and mesenchymal cell states are a crucial form of epithelial plasticity for development and disease progression. Recent experimental data and mechanistic models showed multiple intermediate epithelial-mesenchymal transition (EMT) states as well as trajectories of EMT underpinned by complex gene regulatory networks. In this review, we summarize recent progress in quantifying EMT and characterizing EMT paths with computational methods and quantitative experiments including omics-level measurements. We provide perspectives on how these studies can help relating fundamental cell biology to physiological and pathological outcomes of EMT.
上皮细胞和间充质细胞状态之间的可逆转换是发育和疾病进展中上皮可塑性的一种重要形式。最近的实验数据和机制模型表明，多种中间上皮-间充质转化（EMT）状态以及由复杂基因调控网络支撑的 EMT 轨迹。在这篇综述中，我们总结了用计算方法和定量实验（包括组学水平的测量）来量化 EMT 和描述 EMT 路径的最新进展。我们提供了如何将这些研究将基础细胞生物学与 EMT 的生理和病理结果联系起来的观点。
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