Pediatric Endocrinology Unit, Meir Medical Center, Sackler School of Medicine, Tel-Aviv University, Kfar-Saba, Israel.
Pediatric Nephrology Unit, Meir Medical Center, Sackler School of Medicine, Tel-Aviv University, Kfar-Saba, Israel.
Endocr Pract. 2024 Jun;30(6):564-568. doi: 10.1016/j.eprac.2024.03.390. Epub 2024 Mar 29.
In contrast to adults, primary hyperparathyroidism (PHPT) in children and adolescents is a rare endocrine disorder.
A retrospective review of PHPT cases between 2005 and 2022 from a single tertiary university medical center, including clinical signs and symptoms, laboratory findings, radiological evaluation, treatment, and postoperative complications.
Ten children (mean age at diagnosis 16.3 ± 1.3 years) were diagnosed with PHPT. All patients were in late pubertal stages without sex predominance and 8 were symptomatic. Mean calcium level was 13.6 ± 2.5 mg/dL, and mean parathyroid hormone levels were 204.8 ± 163.1 pg/mL. Parathyroid adenoma was confirmed by the postsurgical pathology results.
PHPT in children and adolescents is often symptomatic and more severe than adults. The main cause is single parathyroid adenoma. Associated hypercalcemic syndromes were not found. Patients were cured after surgical removal of the adenoma without significant postoperative complications and no recurrence during 10.4 ± 5.9 years follow-up.
与成年人不同，儿童和青少年原发性甲状旁腺功能亢进症（PHPT）是一种罕见的内分泌疾病。
对 2005 年至 2022 年期间在一家三级大学医学中心就诊的 PHPT 病例进行回顾性分析，包括临床症状和体征、实验室检查结果、影像学评估、治疗和术后并发症。
诊断出 10 例儿童 PHPT（平均诊断年龄 16.3±1.3 岁）。所有患者均处于晚期青春期，无性别优势，8 例有症状。平均血钙水平为 13.6±2.5mg/dL，甲状旁腺激素水平为 204.8±163.1pg/mL。术后病理结果证实为甲状旁腺腺瘤。
儿童和青少年 PHPT 常为症状性，且比成年人更严重。主要病因是单发甲状旁腺腺瘤。未发现与高钙血症相关的综合征。患者在腺瘤切除后治愈，术后 10.4±5.9 年随访期间无明显并发症且无复发。
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