慢性粒细胞白血病中不寻常的Ph染色体易位：4例新病例

Unusual Ph translocations in CML: four new cases.

作者信息

Sessarego M, Ajmar F, Bianchi Scarrà G L, Ravazzolo R, Garré C, Boccaccio P

出版信息

Cancer Genet Cytogenet. 1985 Feb 15;15(3-4):199-207. doi: 10.1016/0165-4608(85)90163-3.

Abstract

Four variants of the Ph chromosome translocation in chronic myelogenous leukemia (CML) patients are described. Two had an unusual simple translocation involving chromosomes #7 and #17. In two cases, the translocation, aside from involving #9 and #22, involved a third chromosome, chromosome #6 and chromosome #11, respectively. Three cases showed also karyotypic evolution during the blastic phase of the disease: in two cases, a new reciprocal translocation was found that involved a chromosome #9 at band q34. The clinical and cytogenetic significance of these results is briefly discussed.

摘要

描述了慢性粒细胞白血病（CML）患者中费城染色体易位的四种变体。其中两种具有不寻常的简单易位，涉及7号和17号染色体。在另外两例中，除了涉及9号和22号染色体外，易位还分别涉及第三条染色体，即6号染色体和11号染色体。三例患者在疾病的原始细胞期也显示出核型演变：其中两例发现了一种新的相互易位，涉及9号染色体q34带。简要讨论了这些结果的临床和细胞遗传学意义。