5例髓系白血病中具有共同断点6p23的染色体重排。

Chromosomal rearrangements with a common breakpoint at 6p23 in five cases of myeloid leukemia.

作者信息

Fleischman E W, Prigogina E L, Iljinskaja G W, Konstantinova L N, Puchkova G P, Volkova M A, Frenkel M A, Balakirev S A

出版信息

Hum Genet. 1983;64(3):254-6. doi: 10.1007/BF00279404.

Abstract

Rearrangement of the short arm of chromosome 6 with a breakpoint at 6p23 was found in five patients with myeloid leukemia. Three of them had different morphological variants of AML (M2, M3, M4) and two blastic crisis of Ph1 negative and Ph1 positive CML. Identical translocation, t(6;9)(p23;q34), was revealed in two patients. One of them had AML (M2), the other blastic crisis of Ph1 negative CML. The blast cells of the last patient were morphologically similar to those in the M2 variant of AML. Translocation (6;9)(p23;q34) was also detected in two AML patients of Rowley and Potter (1976). The role of the breakpoint at 6p23 in myeloid malignancies needs further investigation.

摘要

在5例髓系白血病患者中发现了6号染色体短臂重排，断点位于6p23。其中3例患有不同形态学变异的急性髓系白血病（M2、M3、M4），2例为Ph1阴性和Ph1阳性慢性髓系白血病的急变期。在2例患者中发现了相同的易位，即t(6;9)(p23;q34)。其中1例患有急性髓系白血病（M2），另1例为Ph1阴性慢性髓系白血病的急变期。最后1例患者的原始细胞在形态上与急性髓系白血病M2变异型的原始细胞相似。Rowley和Potter（1976年）的2例急性髓系白血病患者中也检测到了易位(6;9)(p23;q34)。6p23断点在髓系恶性肿瘤中的作用需要进一步研究。