酒渣鼻患者血浆降钙素基因相关肽水平升高：一项横断面病例对照研究。

Elevated plasma levels of calcitonin gene-related peptide in individuals with rosacea: A cross-sectional case-control study.

作者信息

Wienholtz Nita K F, Christensen Casper E, Ashina Håkan, Jørgensen Niklas R, Egeberg Alexander, Thyssen Jacob P, Ashina Messoud

机构信息

Department of Neurology, Danish Headache Center, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.

Department of Dermatology, Bispebjerg and Frederiksberg, Copenhagen University, Copenhagen, Denmark.

出版信息

J Eur Acad Dermatol Venereol. 2025 Jan;39(1):181-188. doi: 10.1111/jdv.19954. Epub 2024 Apr 1.

DOI:10.1111/jdv.19954

PMID:38558478

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11664452/

Abstract

BACKGROUND

Understanding the role of calcitonin gene-related peptide (CGRP) in the pathogenesis of rosacea might provide new therapeutic avenues for individuals with this disease.

OBJECTIVE

To compare plasma levels of CGRP between individuals with rosacea and healthy controls.

METHODS

In this cross-sectional case-control study conducted in Copenhagen, Denmark, we collected blood samples from the antecubital vein from adults with rosacea and from healthy controls.

RESULTS

We enrolled 123 individuals with rosacea and 68 healthy controls. After adjusting for age and sex, plasma levels of CGRP were significantly higher in individuals with rosacea (mean, 95% confidence interval: 140.21 pmol/L, 128.50-151.92 pmol/L), compared with controls (110.77 pmol/L, 99.91-120.14 pmol/L, p = 0.002). Plasma levels of CGRP were not affected by age, sex, BMI, concomitant migraine, rosacea sub- or phenotype, concomitant disease or current treatment.

LIMITATIONS

Participants were not age-, sex- and BMI-matched.

CONCLUSIONS AND RELEVANCE

Elevated plasma levels of CGRP in individuals with rosacea suggest a role of CGRP in the pathogenesis of rosacea. Targeting CGRP signalling might hold therapeutic promise in people affected by this disease.

GOV LISTING

NCT03872050.

摘要

背景

了解降钙素基因相关肽（CGRP）在酒渣鼻发病机制中的作用可能为该病患者提供新的治疗途径。

目的

比较酒渣鼻患者与健康对照者血浆中CGRP水平。

方法

在丹麦哥本哈根进行的这项横断面病例对照研究中，我们从患有酒渣鼻的成年人和健康对照者的肘前静脉采集血样。

结果

我们纳入了123例酒渣鼻患者和68名健康对照者。在调整年龄和性别后，酒渣鼻患者血浆中CGRP水平显著高于对照组（均值，95%置信区间：140.21 pmol/L，128.50 - 151.92 pmol/L），对照组为（110.77 pmol/L，99.91 - 120.14 pmol/L，p = 0.002）。CGRP血浆水平不受年龄、性别、体重指数、伴发偏头痛、酒渣鼻亚型或表型、伴发疾病或当前治疗的影响。