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过度生长会破坏患口腔癌小鼠的肠道微生物群。

overgrowth disrupts the gut microbiota in mice bearing oral cancer.

作者信息

Wang Xu, Wu Shuangshaung, Li Linman, Yan Zhimin

机构信息

Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.

Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, China.

出版信息

Mycology. 2023 Oct 26;15(1):57-69. doi: 10.1080/21501203.2023.2256761. eCollection 2024.

DOI:10.1080/21501203.2023.2256761
PMID:38558840
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10977010/
Abstract

is one of the most common opportunistic fungi in cancer patients. This study explored the influence of on gut microbiota in oral tumour-bearing mice by means of 16S rRNA sequencing and ITS sequencing. It was found that infection induced the decrease of alpha diversity of bacteria and fungi in the gut microbiome. For the bacteria, caused the reduction of , , , , and . For the fungi, inhibited the growth of other fungi including , , and . The neutralisation of γδT cells partly alleviated the out-of-balance of / (F/B) ratio in the gut caused by infection. However, γδT cell neutralisation boosted the overgrowth of . Additionally, IL-17A neutralisation aggravated the microbial dysbiosis of bacteria and fungi caused by infection. Further analysis indicated that overgrowth might influence the correlations between fungal and bacterial kingdoms. In conclusion, infection disturbed the gut microbiota of both bacteria and fungi in oral tumour-bearing mice, which may be associated with the intestinal immune components including γδT cells and IL-17A.

摘要

是癌症患者中最常见的机会性真菌之一。本研究通过16S rRNA测序和ITS测序，探讨了其对口腔荷瘤小鼠肠道微生物群的影响。研究发现，感染导致肠道微生物群中细菌和真菌的α多样性降低。对于细菌，导致、、、和减少。对于真菌，抑制了包括、和在内的其他真菌的生长。γδT细胞的中和部分缓解了感染引起的肠道中/（F/B）比值失衡。然而，γδT细胞中和促进了的过度生长。此外，IL-17A中和加剧了感染引起的细菌和真菌的微生物失调。进一步分析表明，的过度生长可能影响真菌和细菌界之间的相关性。总之，感染扰乱了口腔荷瘤小鼠肠道中的细菌和真菌微生物群，这可能与包括γδT细胞和IL-17A在内的肠道免疫成分有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5a3/10977010/458c505ea7b7/TMYC_A_2256761_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5a3/10977010/a486d8b71dcb/TMYC_A_2256761_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5a3/10977010/afa2f2c2204e/TMYC_A_2256761_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5a3/10977010/b0e6ef366628/TMYC_A_2256761_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5a3/10977010/c8a0268b25b8/TMYC_A_2256761_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5a3/10977010/458c505ea7b7/TMYC_A_2256761_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5a3/10977010/a486d8b71dcb/TMYC_A_2256761_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5a3/10977010/afa2f2c2204e/TMYC_A_2256761_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5a3/10977010/b0e6ef366628/TMYC_A_2256761_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5a3/10977010/c8a0268b25b8/TMYC_A_2256761_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5a3/10977010/458c505ea7b7/TMYC_A_2256761_F0005_OC.jpg

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引用本文的文献

[1]
The Vps21 signalling pathway regulates white-opaque switching and mating in .

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[2]
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[3]
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[4]
Fungal footprints in oral cancer: unveiling the oral mycobiome.

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本文引用的文献

[1]
Candida albicans Promotes Oral Cancer via IL-17A/IL-17RA-Macrophage Axis.

mBio. 2023-6-27

[2]
Is Candida albicans a contributor to cancer? A critical review based on the current evidence.

Microbiol Res. 2023-7

[3]
The Firmicutes/Bacteroidetes Ratio as a Risk Factor of Breast Cancer.

J Clin Med. 2023-3-13

[4]
can foster gut dysbiosis and systemic inflammation during HIV infection.

Gut Microbes. 2023

[5]
Context-Dependent Regulation of Type17 Immunity by Microbiota at the Intestinal Barrier.

Immune Netw. 2022-9-26

[6]
Oral Microbiota from Periodontitis Promote Oral Squamous Cell Carcinoma Development via γδ T Cell Activation.

mSystems. 2022-10-26

[7]
TCR-Vγδ usage distinguishes protumor from antitumor intestinal γδ T cell subsets.

Science. 2022-7-15

[8]
Altered Gut Microbiome Composition and Function Are Associated With Gut Barrier Dysfunction in Healthy Relatives of Patients With Crohn's Disease.

Gastroenterology. 2022-11

[9]
Fecal Is Associated with Clinical Remission and Endoscopic Response following Fecal Microbiota Transplantation in Mild-to-Moderate Ulcerative Colitis.

Microorganisms. 2022-3-29

[10]
Cancer pharmacomicrobiomics: targeting microbiota to optimise cancer therapy outcomes.

Gut. 2022-7

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