Department of Infectious Diseases, Chongqing Public Health Medical Center, Chongqing, China.
Clinical Research Center, Chongqing Public Health Medical Center, Chongqing, China.
Gut Microbes. 2023 Jan-Dec;15(1):2167171. doi: 10.1080/19490976.2023.2167171.
is a ubiquitous fungal commensal component of the human microbiota, and under certain circumstances, such as during an immunocompromised state, it may initiate different types of infection. Moreover, continuously and reciprocally interacts with the host immune system as well as with other elements of the gut microbiota, thus contributing significantly to both gut homeostasis and host immunity. People living with HIV (PLWH), including those receiving antiretroviral therapy, are characterized by a depletion of CD4 + T-cells and dysbiosis in their gut. colonization is frequent in PLWH, causing both a high prevalence and high morbidity. Gut barrier damage and elevated levels of microbial translocation are also fairly common in this population. Herein, we take a closer look at the reciprocity among , gut microbiota, HIV, and the host immune system, thus throwing some light on this complex interplay.
是人类微生物群中的一种普遍存在的真菌共生体，在某些情况下，如免疫功能低下时，它可能会引发不同类型的感染。此外，它还与宿主免疫系统以及肠道微生物群的其他成员持续地相互作用，因此对肠道稳态和宿主免疫都有重要贡献。人类免疫缺陷病毒（HIV）感染者，包括接受抗逆转录病毒治疗的患者，其特征是 CD4+T 细胞耗竭和肠道菌群失调。 在 HIV 感染者中很常见，导致高患病率和高发病率。肠道屏障损伤和微生物易位水平升高在这一人群中也很常见。在此，我们仔细研究了 、肠道微生物群、HIV 和宿主免疫系统之间的互惠关系，从而深入了解这种复杂的相互作用。
