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在一名反复发生艰难梭菌感染的患者中偶然发现肝结节病。

Hepatic Sarcoidosis Found Incidentally in a Patient Presenting With Recurrent Clostridium difficile Infections.

作者信息

Mitchell Richard, Khan Haidar, Reyes Jonathan Vincent M

机构信息

Internal Medicine, Icahn School of Medicine at Mount Sinai/NYC Health + Hospitals-Elmhurst, Queens, USA.

出版信息

Cureus. 2024 Mar 1;16(3):e55316. doi: 10.7759/cureus.55316. eCollection 2024 Mar.

DOI:10.7759/cureus.55316
PMID:38559541
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10981841/
Abstract

A 50-year-old female who presented to our hospital for recurrent diarrhea was found to have worsening aminotransferase and alkaline phosphatase levels. Workup revealed lymphadenopathy and hepatomegaly prompting a biopsy of the liver and axillary lymph node, confirming a diagnosis of hepatic sarcoidosis. Our patient later developed cutaneous sarcoidosis. She is currently asymptomatic and is followed by gastroenterology, pulmonary, and dermatology. Recognition of extrapulmonary manifestations of sarcoidosis is important for proper management of patients. Treatment often requires a multidisciplinary approach when more than one organ system is involved.

摘要

一名50岁女性因反复腹泻前来我院就诊,检查发现其转氨酶和碱性磷酸酶水平不断恶化。进一步检查发现有淋巴结病和肝肿大,于是对肝脏和腋窝淋巴结进行活检,确诊为肝结节病。我们的患者后来又出现了皮肤结节病。她目前没有症状,由胃肠病学、肺病学和皮肤病学科室进行随访。认识结节病的肺外表现对于患者的正确管理很重要。当涉及多个器官系统时,治疗通常需要多学科方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b2/10981841/8828d6ac1933/cureus-0016-00000055316-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b2/10981841/e44b90b0e45e/cureus-0016-00000055316-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b2/10981841/8828d6ac1933/cureus-0016-00000055316-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b2/10981841/e44b90b0e45e/cureus-0016-00000055316-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b2/10981841/8828d6ac1933/cureus-0016-00000055316-i02.jpg

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本文引用的文献

1
Hepatic Sarcoidosis: Incidence, Monitoring, and Treatment.肝结节病:发病率、监测与治疗
Clin Liver Dis (Hoboken). 2020 Dec 10;16(5):208-211. doi: 10.1002/cld.1002. eCollection 2020 Nov.
2
Hepatic Sarcoidosis: An Uncommon Cause of Cirrhosis.肝结节病:肝硬化的罕见病因
Cureus. 2019 Dec 6;11(12):e6316. doi: 10.7759/cureus.6316.
3
Hepatic Sarcoidosis Complicated with Pancreatic Adenocarcinoma.肝结节病合并胰腺腺癌
Case Reports Hepatol. 2019 Nov 19;2019:9383019. doi: 10.1155/2019/9383019. eCollection 2019.
4
Hepatic Sarcoidosis: Natural History and Management Implications.肝结节病:自然史及管理意义
Front Med (Lausanne). 2019 Oct 30;6:232. doi: 10.3389/fmed.2019.00232. eCollection 2019.
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Hepatic sarcoidosis with atypical radiological manifestations: A case report.具有非典型影像学表现的肝结节病:一例报告
Radiol Case Rep. 2018 Jul 24;13(5):936-939. doi: 10.1016/j.radcr.2018.06.013. eCollection 2018 Oct.
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Hepatic sarcoidosis mimicking cholangiocellular carcinoma: A case report and literature review.酷似胆管细胞癌的肝结节病:一例报告及文献复习
Int J Surg Case Rep. 2017;41:165-168. doi: 10.1016/j.ijscr.2017.10.032. Epub 2017 Oct 25.
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Clinical Characteristics and Outcome of Hepatic Sarcoidosis: A Population-Based Study 1976-2013.肝结节病的临床特征与转归:一项基于人群的1976 - 2013年研究
Am J Gastroenterol. 2017 Oct;112(10):1556-1563. doi: 10.1038/ajg.2017.231. Epub 2017 Sep 5.
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Long-Term Outcomes of Liver Transplantation for Hepatic Sarcoidosis: A Single Center Experience.肝结节病肝移植的长期预后:单中心经验
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Sarcoidosis manifesting as hepatic and splenic nodules mimicking ovarian cancer metastases: A case report.表现为模仿卵巢癌转移的肝脾结节的结节病:一例报告。
Oncol Lett. 2015 Oct;10(4):2166-2170. doi: 10.3892/ol.2015.3566. Epub 2015 Aug 4.
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Hepatic Sarcoidosis.肝结节病。
J Clin Transl Hepatol. 2013 Dec;1(2):87-93. doi: 10.14218/JCTH.2013.00016. Epub 2013 Dec 15.