Gupta Kamesh, Hassan Tuyyab, Rizwan Shahid, Hans Bandhul, Jawale Rahul, Desilets David
Department of Internal Medicine, UMMS-Baystate, Springfield, MA, USA.
Department of Gastroenterology, UMMS-Baystate, Springfield, MA, USA.
Case Reports Hepatol. 2019 Nov 19;2019:9383019. doi: 10.1155/2019/9383019. eCollection 2019.
Sarcoidosis is a systemic noncaseous granulomatous disease. The liver is a common location but usually asymptomatic. Current literature suggests an association between sarcoidosis and cancers. However, there is a lack of definite evidence. We present a case of a 59-year-old man with jaundice and acutely elevated alkaline phosphatase. The diagnosis was confirmed by obtaining a liver biopsy and was treated with 6 months of steroids. A year later, he had a recurrence of jaundice. MRCP showed biliary dilatation and a mass in the pancreatic head, confirmed by biopsy to be adenocarcinoma. This is the first case to be reported of hepatic sarcoidosis associated with pancreatic cancer.
结节病是一种全身性非干酪样肉芽肿性疾病。肝脏是常见受累部位,但通常无症状。目前的文献表明结节病与癌症之间存在关联。然而,缺乏确凿证据。我们报告一例59岁男性,出现黄疸且碱性磷酸酶急剧升高。通过肝活检确诊,并接受了6个月的类固醇治疗。一年后,他黄疸复发。磁共振胰胆管造影(MRCP)显示胆管扩张及胰头肿块,活检证实为腺癌。这是首例报告的肝结节病合并胰腺癌病例。