Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Shandong Center for Disease Control and Prevention, Ji'nan, Jinan, Shandong, China.
BMC Pediatr. 2024 Apr 1;24(1):222. doi: 10.1186/s12887-024-04680-8.
To investigate the relationship between body mass index (BMI) and blood biochemical indicators in early adolescence, and to provide ideas for early prevention of diseases and explore possible disease-related predictors.
3125 participants aged 10 ∼ 14 years were selected from China from the survey of "China Nutrition and Health Surveillance ( 2016 ∼ 2017 ) ". Employing advanced statistical methods, including generalized linear models, heatmaps, hierarchical clustering, and generalized additive models, the study delved into the associations between BMI and various biochemical indicators.
In early adolescence, indicators including systolic pressure, diastolic pressure, weight, height, BMI, hemoglobin, blood uric acid, serum creatinine, albumin, vitamin A presented increasing trends with the increase of age ( P < 0.05 ), whereas LDL-C, vitamin D, and ferritin showed decreasing trends with the increase of age ( P < 0.05 ). The increase in hemoglobin and blood uric acid levels with age was more pronounced in males compared to females ( P < 0.05 ). BMI was positively correlated with blood glucose, hemoglobin, triglyceride, LDL-C, blood uric acid, serum creatinine, ferritin, transferrin receptor, hs-CRP, total protein, vitamin A ( P < 0.05 ). There was a significant BMI × age interaction in the correlation analysis with LDL-C, transferrin receptor, serum creatinine, and hs-CRP ( P < 0.05 ). BMI was a risk factor for hypertension, hypertriglyceridemia, low high density lipoprotein cholesterolemia, and metabolic syndrome in all age groups ( OR > 1, P < 0.05 ).
High BMI was a risk factor for hypertension, hypertriglyceridemia, low high density lipoprotein cholesterolemia, and MetS in early adolescents. With the focus on energy intake beginning in early adolescence, the maintenance of a healthy weight warrants greater attention.
探讨青少年早期体重指数（BMI）与血液生化指标的关系，为疾病的早期预防提供思路，并探索可能的疾病相关预测指标。
本研究从中国“2016—2017 年中国居民营养与健康状况监测”中选取了 3125 名 10~14 岁的参与者。采用广义线性模型、热图、层次聚类和广义加性模型等先进的统计方法，探讨了 BMI 与各种生化指标之间的关系。
青少年早期，收缩压、舒张压、体重、身高、BMI、血红蛋白、血尿酸、血清肌酐、白蛋白、维生素 A 等指标随年龄增长呈上升趋势（P<0.05），而 LDL-C、维生素 D 和铁蛋白则随年龄增长呈下降趋势（P<0.05）。与女性相比，男性血红蛋白和血尿酸水平随年龄的增长更为明显（P<0.05）。BMI 与血糖、血红蛋白、甘油三酯、LDL-C、血尿酸、血清肌酐、铁蛋白、转铁蛋白受体、hs-CRP、总蛋白、维生素 A 呈正相关（P<0.05）。在 LDL-C、转铁蛋白受体、血清肌酐和 hs-CRP 的相关性分析中，BMI 与年龄存在显著的交互作用（P<0.05）。在所有年龄组中，BMI 均是高血压、高甘油三酯血症、低高密度脂蛋白胆固醇血症和代谢综合征的危险因素（OR>1，P<0.05）。
青少年早期，高 BMI 是高血压、高甘油三酯血症、低高密度脂蛋白胆固醇血症和代谢综合征的危险因素。因此，从青少年早期开始关注能量摄入，对于维持健康体重至关重要。
