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绦虫如何与癌症相互作用:小型综述。

How tapeworms interact with cancers: a mini-review.

机构信息

Department of Parasitology, Faculty of Science, Charles University Prague, Prague, Czech Republic.

出版信息

PeerJ. 2024 Mar 29;12:e17196. doi: 10.7717/peerj.17196. eCollection 2024.

Abstract

Cancer is one of the leading causes of death, with an estimated 19.3 million new cases and 10 million deaths worldwide in 2020 alone. Approximately 2.2 million cancer cases are attributed to infectious diseases, according to the World Health Organization (WHO). Despite the apparent involvement of some parasitic helminths (especially trematodes) in cancer induction, there are also records of the potential suppressive effects of helminth infections on cancer. Tapeworms such as , , and more seem to have the potential to suppress malignant cell development, although in a few cases the evidence might be contradictory. Our review aims to summarize known epidemiological data on the cancer-helminth co-occurrence in the human population and the interactions of tapeworms with cancers, ., proven or hypothetical effects of tapeworms and their products on cancer cells (., in experimental animals) or . The prospect of bioactive tapeworm molecules helping reduce the growth and metastasis of cancer is within the realm of future possibility, although extensive research is yet required due to certain concerns.

摘要

癌症是导致死亡的主要原因之一,仅 2020 年一年,全球就有估计 1930 万例新发病例和 1000 万人死亡。根据世界卫生组织(WHO)的数据,约有 220 万例癌症病例归因于传染病。尽管一些寄生虫(特别是吸虫)显然参与了癌症的诱导,但也有寄生虫感染对癌症具有潜在抑制作用的记录。绦虫,如,和更多的似乎有可能抑制恶性细胞的发展,尽管在某些情况下,证据可能是矛盾的。我们的综述旨在总结人类群体中癌症与寄生虫共同发生的已知流行病学数据,以及绦虫与癌症的相互作用,. 已经证明或假设的绦虫及其产物对癌细胞的影响 (. 在实验动物中)或. 具有生物活性的绦虫分子有助于减少癌症的生长和转移的前景是未来的可能性范围内,尽管由于某些担忧,还需要进行广泛的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b951/10984186/2fc47e8a4c1e/peerj-12-17196-g001.jpg

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