Department of Biophysics, Post Graduate Institute of Medical Education & Research (PGIMER), Chandigarh, 160012, India.
Med Oncol. 2024 Jul 29;41(9):211. doi: 10.1007/s12032-024-02458-7.
Despite recent advances in the management and therapeutic of cancer, the treatment of the disease is limited by its high cost and severe side effects. In this scenario, there is an unmet need to identify novel treatment alternatives for this dreaded disease. Recently there is growing evidence that parasites may cause anticancer effects because of a negative correlation between parasitic infections and tumour growth despite some parasites that are known to exhibit pro-carcinogenic effects. It has been observed that parasites exert an anticancer effect either by activating the host's immune response or by secreting certain molecules that exhibit anticancer potential. The activation of the immune response by these parasitic organisms results in the inhibition of some of the hallmarks of cancer such as tumour proliferation, angiogenesis, and metastasis. This review summarizes the current advances as well as the mechanisms underlying the possible implications of this diverse group of organisms as anticancer agents.
尽管癌症的治疗和管理在最近取得了进展，但由于其高成本和严重的副作用，该疾病的治疗仍然受到限制。在这种情况下，需要确定新的治疗方法来治疗这种可怕的疾病。最近有越来越多的证据表明寄生虫可能具有抗癌作用，因为寄生虫感染与肿瘤生长之间存在负相关，尽管有些寄生虫已知具有致癌作用。已经观察到寄生虫通过激活宿主的免疫反应或分泌具有抗癌潜力的某些分子来发挥抗癌作用。这些寄生虫通过激活免疫反应来抑制肿瘤增殖、血管生成和转移等一些癌症的标志。这篇综述总结了这些生物体作为抗癌药物的可能作用机制及目前的研究进展。
