Sun Nai-Xian, Wang Le-Cheng, Fang Zheng, Wang Chang-Sheng, Guo Kai, Wu Xiao-Feng
College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China.
Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023 Dalian, Liaoning China.
Org Lett. 2024 Apr 19;26(15):3140-3144. doi: 10.1021/acs.orglett.4c00726. Epub 2024 Apr 2.
Carbonylative multifunctionalization of alkenes is an efficient approach to introduce multiple functional groups into one molecule from easily available materials. Herein, we developed an iron-catalyzed radical relay carbonylative cyclization of alkenes with acetamides. Various α-tetralones can be constructed in moderate yields from readily available substrates with an earth-abundant iron salt as the catalyst.
烯烃的羰基化多功能化是一种从易得原料将多个官能团引入一个分子的有效方法。在此，我们开发了一种铁催化的烯烃与乙酰胺的自由基接力羰基化环化反应。以储量丰富的铁盐为催化剂，从易得的底物出发，能够以中等产率构建各种α-四氢萘酮。
