Barden A, Beilin L J, Vandongen R, Rouse I
Clin Sci (Lond). 1985 May;68(5):601-4. doi: 10.1042/cs0680601.
Measurement of urinary 6-ketoprostaglandin (PG) F1 alpha and PGE2 excretion in 83 healthy children, aged 5-15 years, revealed that supervised 4 h urine collections under mild water diuresis provided more consistent results than overnight 12 h urine collections. Males had higher urinary excretion of 6-keto-PGF1 alpha but not of PGE2 compared with females. Urinary potassium was related to 6-keto-PGF1 alpha in both 4 and 12 h urine collections and urinary sodium to 6-keto-PGF1 alpha in 4 h collections only. In the sexes combined multiple regression analyses revealed age as the only significant influence on prostanoid excretion (P = 0.001). Thus age and sex and dietary potassium intake need to be considered in studies of urinary prostanoids in children.
对83名5至15岁健康儿童尿中6-酮前列腺素（PG）F1α和PGE2排泄量的测量显示，在轻度水利尿情况下进行4小时的监督尿液收集，比12小时的夜间尿液收集能提供更一致的结果。与女性相比，男性尿中6-酮-PGF1α排泄量较高，但PGE2排泄量并非如此。在4小时和12小时的尿液收集样本中，尿钾均与6-酮-PGF1α相关，而仅在4小时的收集样本中尿钠与6-酮-PGF1α相关。在综合两性的多元回归分析中，年龄是对类前列腺素排泄唯一有显著影响的因素（P = 0.001）。因此，在儿童尿类前列腺素的研究中，需要考虑年龄、性别和饮食中钾的摄入量。
