Rubin P D, Murthy V S, Hansen R G, Pietrowiak C
Prostaglandins Leukot Med. 1987 May;27(2-3):105-17. doi: 10.1016/0262-1746(87)90064-3.
The existence of diurnal variation in renal function is well described. Prostaglandins are intimately involved with renal physiology, yet a diurnal variation in their excretion is not well documented. We collected 12 consecutive 2 hour urine specimens from 10 young healthy females and measured prostaglandin E2 [PGE2], thromboxane B2 [TXB2], and 6-keto-prostaglandin-F1-alpha by radioimmunoassay for each specimen. We also measured urine volume, urine sodium, and urine creatinine levels. Regression analysis was used to determine the best sine curve for time versus each set of mean values. Only the urinary excretion of PGE2 and TXB2, as well as water were found to significantly fit the generated sine curves. The curves for PGE2 and TXB2 showed a temporal dissociation in their peak and trough values. The excretion of PGE2 between 0800 hours and 2000 hours was significantly higher than during the hours of 2000 and 0800. The opposite was true for the TXB2 excretion. This data suggests that these two prostaglandins and water are excreted in a sine wave pattern. It also suggests that the excretion of PGE2 and TXB2 may respond to different time associated stimuli. We also showed a significant correlation between PGE2 excretion and both the excretion of water and sodium.
肾功能存在昼夜变化，这已得到充分描述。前列腺素与肾脏生理密切相关，但其排泄的昼夜变化尚无充分记录。我们从10名年轻健康女性中连续收集了12份2小时的尿液标本，并通过放射免疫分析法对每份标本测量前列腺素E2 [PGE2]、血栓素B2 [TXB2]和6-酮-前列腺素-F1-α。我们还测量了尿量、尿钠和尿肌酐水平。采用回归分析来确定时间与每组平均值之间的最佳正弦曲线。结果发现，只有PGE2和TXB2的尿排泄量以及水分显著符合生成的正弦曲线。PGE2和TXB2的曲线在峰值和谷值上呈现出时间上的分离。08:00至20:00期间PGE2的排泄量显著高于20:00至08:00期间。TXB2的排泄情况则相反。这些数据表明，这两种前列腺素和水分以正弦波模式排泄。这也表明PGE2和TXB2的排泄可能对不同的时间相关刺激做出反应。我们还发现PGE2排泄与水分和钠的排泄之间存在显著相关性。
