Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
Neurosci Biobehav Rev. 2024 Jun;161:105648. doi: 10.1016/j.neubiorev.2024.105648. Epub 2024 Mar 31.
This narrative review describes the research on the effects of the association between environmental context and medications, suggesting the benefit of specific design interventions in adjunction to pharmacotherapy. The literature on Evidence-Based Design (EBD) studies and Neuro-Architecture show how contact with light, nature, and specific physical features of urban and interior architecture may enhance the effects of analgesic, anxiolytics, and antidepressant drugs. This interaction mirrors those already known between psychedelics, drugs of abuse, and setting. Considering that the physical feature of space is a component of the complex placebo configuration, the aim is to highlight those elements of built or natural space that may help to improve drug response in terms of efficacy, tolerability, safety, and compliance. Ecocebo, the integration of design approaches such as EBD and Neuro-Architecture may thus contribute to a more efficient, cost-sensitive, and sustainable pharmacotherapy.
这篇叙述性评论描述了环境背景与药物之间关联的研究，表明特定设计干预措施与药物治疗联合应用的益处。有关循证设计（EBD）研究和神经建筑学的文献表明，接触光线、自然以及城市和室内建筑的特定物理特征可能会增强镇痛药、抗焦虑药和抗抑郁药的效果。这种相互作用反映了迷幻剂、滥用药物和环境之间已经存在的相互作用。考虑到空间的物理特征是复杂安慰剂结构的一个组成部分，其目的是强调建筑或自然空间中可能有助于提高药物疗效、耐受性、安全性和顺应性的那些元素。因此，生态安慰剂（Ecocebo），即循证设计和神经建筑学等设计方法的整合，可能有助于实现更高效、更具成本效益和更可持续的药物治疗。
