慢性皮肤型红斑狼疮患者的人类组织相容性抗原关联

Human histocompatibility antigen associations in patients with chronic cutaneous lupus erythematosus.

作者信息

Fowler J F, Callen J P, Stelzer G T, Cotter P K

出版信息

J Am Acad Dermatol. 1985 Jan;12(1 Pt 1):73-7. doi: 10.1016/s0190-9622(85)70012-6.

Abstract

Increased frequency of certain human leukocyte antigens (HLA) has been reported in various subsets of patients with lupus erythematosus (LE). Specifically, HLA-B8 and HLA-DR3 have been associated with subacute cutaneous LE; HLA-DR3 or HLA-DR2 is found in mothers of infants with neonatal LE; and HLA-A1, HLA-B8, HLA-B15, and HLA-DR2 occur in patients with systemic LE. We typed twenty-two white and nineteen black patients with chronic cutaneous (discoid) LE (DLE) for the A, B, and DR loci of the HLA antigens. HLA-DRw6 was found in an increased proportion of our patients of both races compared with controls. HLA-B8 was found more frequently in white DLE patients than in white control subjects. Thus a genetic predisposition may be a factor that explains the variation in disease expression.

摘要

据报道，在红斑狼疮（LE）患者的不同亚组中，某些人类白细胞抗原（HLA）的频率增加。具体而言，HLA - B8和HLA - DR3与亚急性皮肤型LE相关；新生儿LE患儿的母亲中发现有HLA - DR3或HLA - DR2；系统性LE患者中出现HLA - A1、HLA - B8、HLA - B15和HLA - DR2。我们对22名白人慢性皮肤（盘状）LE（DLE）患者和19名黑人慢性皮肤（盘状）LE患者进行了HLA抗原A、B和DR位点分型。与对照组相比，我们两个种族的患者中HLA - DRw6的比例均有所增加。白人DLE患者中HLA - B8的出现频率高于白人对照受试者。因此，遗传易感性可能是解释疾病表现差异的一个因素。