Millard L G, Rowell N R, Rajah S M
Br J Dermatol. 1977 Feb;96(2):139-44. doi: 10.1111/j.1365-2133.1977.tb12535.x.
A study of histocompatibility (HLA) antigens in 69 patients with discoid lupus erythematosus (DLE) showed an increased incidence of HLA-B7 and HLA-B8 related to the age at onset and sex of the patient. Young females and males aged 15-39 years at onset were associated with HLA-B7 and females aged over 40 years with HLA-B8. This supports previous studies concerning sex and age specific onset rates in DLE which suggests that there is more than one genotype in this disorder. Female patients with systemic lupus erythematosus (SLE) at all ages of onset showed a significant association with HLA-B8. Female patients, with onset 15-39 years, with either SLE or DLE which has transformed to SLE, show a significant increase in HLA-B8 compared with the females in the same age onset group who have the discoid disease. The presence of HLA-B8 in a young female with DLE may represent a risk factor for the development of the systemic disease.
一项对69例盘状红斑狼疮（DLE）患者进行的组织相容性（HLA）抗原研究表明，HLA - B7和HLA - B8的发生率与患者的发病年龄和性别有关。发病时年龄在15 - 39岁的年轻女性和男性与HLA - B7相关，发病时年龄超过40岁的女性与HLA - B8相关。这支持了先前关于DLE性别和年龄特异性发病率的研究，表明该疾病存在不止一种基因型。所有发病年龄的系统性红斑狼疮（SLE）女性患者均与HLA - B8显著相关。发病年龄在15 - 39岁的患有SLE或已转变为SLE的DLE女性患者，与同年龄发病组患有盘状疾病的女性相比，HLA - B8显著增加。年轻女性DLE患者中HLA - B8的存在可能代表发生系统性疾病的危险因素。
