Stastny P, Gilliam J N
Transplant Proc. 1979 Dec;11(4):1869-70.
Subacute cutaneous LE was identified by the presence of widespread nonscarring skin lesions with histologic features of LE. The HLA antigens A1,B8,DRw3 were increased in patients with this condition. The frequency of DRw3 in this group was 77% compared to 24% in controls (p less than 0.001). The relative risk with HLA-DRw3 for the subacute cutaneous LE group was 10.8 (p less than 0.001). HLA-A1,B8 antigens were not increased in discoid LE or in the systemic LE group. The results illustrate the value of identifying homogeneous groups of patients for finding meaningful HLA associations.
亚急性皮肤型红斑狼疮通过广泛存在的无瘢痕皮肤病变及红斑狼疮的组织学特征得以确诊。患有此病的患者中，HLA抗原A1、B8、DRw3有所增加。该组中DRw3的频率为77%，而对照组为24%（p小于0.001）。亚急性皮肤型红斑狼疮组与HLA - DRw3相关的相对风险为10.8（p小于0.001）。盘状红斑狼疮组或系统性红斑狼疮组中HLA - A1、B8抗原未增加。这些结果说明了识别同类患者群体以发现有意义的HLA关联的价值。
