Ghazi Narges, Saghravanian Nasrollah, Mirhashemi Majid, Shahabi Hamidreza
Department of Oral and Maxillofacial Pathology, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
Indian J Otolaryngol Head Neck Surg. 2024 Apr;76(2):1785-1790. doi: 10.1007/s12070-023-04411-y. Epub 2023 Dec 11.
Oral lichen planus (OLP) is a T-cell-mediated chronic inflammatory disease classified as an oral potentially malignant disorder (OPMD) and increased transformation risk to oral cancer. Oral lichenoid reactions (OLRs) share the clinical manifestations of OLP. This study aimed to determine histomorphometric changes in OLPs and OLRs in comparison to the healthy control, which helps to plan for the establishment of diagnostic criteria.
This cross-sectional prospective study was conducted on a total of 75 tissue-embedded paraffin-block samples, including OLPs (n = 25), OLR cases (n = 25), and healthy control individuals (n = 25). The study groups were compared by chi-squared, Fisher's exact, and one-way ANOVA tests. A -value less than 0.05 was considered statistically significant.
Comparison of the nuclear area and cellular area showed a statistically significant difference between study groups in basal and parabasal layer (P < 0.05). Comparison of the nuclear-to-cytoplasm ratio showed a statistically significant difference between study groups in basal (P < 0.05) but not in the parabasal region (P = 0.681).
We showed a significant difference in the nuclear and cellular area, nuclear-to-cytoplasm ratio between OLPs and OLRs, and healthy controls, but there was no statistically significant difference between OLPs and OLRs. Thus, these parameters cannot be applied to differentiate diagnoses between OLPs and OLRs.
口腔扁平苔藓（OLP）是一种由T细胞介导的慢性炎症性疾病，被归类为口腔潜在恶性疾病（OPMD），其向口腔癌的转化风险增加。口腔苔藓样反应（OLR）与OLP具有相同的临床表现。本研究旨在确定OLP和OLR与健康对照相比的组织形态计量学变化，这有助于制定诊断标准。
本横断面前瞻性研究共纳入75个组织包埋石蜡块样本，包括OLP（n = 25）、OLR病例（n = 25）和健康对照个体（n = 25）。通过卡方检验、Fisher精确检验和单因素方差分析对研究组进行比较。P值小于0.05被认为具有统计学意义。
核面积和细胞面积的比较显示，研究组在基底层和副基底层存在统计学显著差异（P < 0.05）。核质比的比较显示，研究组在基底层存在统计学显著差异（P < 0.05），但在副基底层无统计学显著差异（P = 0.681）。
我们发现OLP、OLR与健康对照之间在核面积、细胞面积和核质比方面存在显著差异，但OLP与OLR之间无统计学显著差异。因此，这些参数不能用于区分OLP和OLR的诊断。
