白内障手术后联合使用地塞米松和左氧氟沙星的临床经验。
Clinical Experience of Using a Combination of Dexamethasone and Levofloxacin After Cataract Surgery.
机构信息
Department of Ophthalmology, University Hospital Center Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia.
Department of Ophthalmology, Dubrava University Hospital, School of Medicine, University of Zagreb, Zagreb, Croatia.
出版信息
Med Arch. 2024;78(2):127-130. doi: 10.5455/medarh.2024.78.127-130.
BACKGROUND
Where routine prophylactic antibiotics have been adopted following cataract surgery, rates of endophthalmitis have been decreasing. Intracameral and topical antibiotics are currently used to prevent endophthalmitis after cataract surgery. When applying topical antibiotics, there are different recommendations on the frequency and duration of therapy. The development of bacterial resistance to the excessive and long-term use of antibiotics is a growing problem worldwide. The goal is to achieve a good antibiotic effect with the shortest possible use of antibiotics.
OBJECTIVE
The aim of this study was to compare the effectiveness of a new combination therapy of dexamethasone and levofloxacin for seven days after cataract surgery with the previous regimen of dexamethasone, neomycin sulfate, and polymyxin B, which was given for 21 days.
METHODS
A retrospective analysis of medical records and administered a questionnaire was conducted to assess the effectiveness of postoperative therapy in our cataract surgery patients. The study involved 52 patients who underwent surgery within the last year, performed by a single surgeon at our institution. The findings can help us improve the quality of care we provide and optimize our patients' overall quality of life.
RESULTS
We conducted an in-depth study on 52 individuals who underwent cataract surgery at our institution. The prescribed therapeutic regimen for the participants included administering Ducressa solution four times daily for the first seven days and Maxidex solution three times daily for the subsequent 14 days. The study found that none of the participants experienced complications after surgery, and all found it easy to instill the medication. The prescribed regimen effectively managed the postoperative recovery of the participants, and the medication was well-tolerated.
CONCLUSION
Our research found that a new combination of levofloxacin and dexamethasone, when used topically, may require a shorter treatment period, reducing the risk of antibiotic resistance and providing a safe alternative for endophthalmitis prevention.
背景
在白内障手术后常规采用预防性抗生素治疗后，眼内炎的发生率有所下降。目前在白内障手术后使用眼内和局部抗生素来预防眼内炎。当使用局部抗生素时，治疗的频率和持续时间有不同的建议。抗生素的过度和长期使用导致细菌耐药性的发展是一个全球性的日益严重的问题。目标是在最短的时间内使用抗生素，达到良好的抗生素效果。
目的
本研究旨在比较白内障手术后 7 天应用新的地塞米松联合左氧氟沙星组合疗法与以往地塞米松、硫酸新霉素和多粘菌素 B 联合治疗 21 天的疗效。
方法
对我们白内障手术患者的术后治疗效果进行了病历回顾性分析和问卷调查。这项研究涉及了 52 名在过去一年内在我们机构接受手术的患者，均由同一位外科医生进行手术。研究结果可以帮助我们提高提供的护理质量，并优化患者的整体生活质量。
结果
我们对 52 名在我们机构接受白内障手术的个体进行了深入研究。参与者的治疗方案包括在最初的 7 天内每天滴注 Ducressa 溶液 4 次，随后的 14 天内每天滴注 Maxidex 溶液 3 次。研究发现，手术后没有参与者出现并发症，并且所有参与者都发现滴注药物很容易。该方案有效地管理了参与者的术后恢复，并且药物耐受性良好。
结论
我们的研究发现，局部应用左氧氟沙星和地塞米松的新组合可能需要更短的治疗期，降低抗生素耐药的风险，并为预防眼内炎提供一种安全的替代方案。
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