Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
Department of Nutritional Science and Food Safety, Faculty of Applied Biosciences, Tokyo University of Agriculture, Tokyo, Japan.
Med Arch. 2024;78(2):177-179. doi: 10.5455/medarh.2024.78.177-179.
Myocarditis refers to myocardial inflammation with necrosis caused by non-infectious of infectious agents such as bacteria, fungi, or drugs. Candida is known to cause myocarditis in healthy and immunocompromised individuals. Diabetes mellitus causes chronic hyperglycemia due to impaired secretion or hypofunction of insulin, induces a compromised state, and increases the risk of contracting various infections.
We report a case of granulomatous myocarditis caused by Candida in a Spontaneously Diabetic Torii rat, a non-obese diabetic model.
A male SDT rat, 61 weeks of age, was housed in conventional environment. The rat was provided a commercial diet and tap water ad libitum. The heart was sampled and prepared the specimen of hematoxylin-and-eosin-, Sirius-red-, Giemsa-, Grocott-stain. Histologically, formation of large granulation tissue was observed in the left ventricular wall. A center of the foci showed necrosis. Moreover, inflammatory cells infiltration and fibrous component were increased surrounding the foci and between myocardial cells. A Grocott and Giemsa staining-positive cell masses occasionally appearing in the foci were considered to be Candida because of their characteristic form.
The development and progression of myocarditis were potentially related to a diabetes-induced compromised state.
心肌炎是指由细菌、真菌或药物等非传染性或传染性病原体引起的心肌炎症伴坏死。已知念珠菌可在健康人和免疫功能低下的个体中引起心肌炎。糖尿病由于胰岛素分泌不足或功能障碍导致慢性高血糖，引起代偿状态，增加感染各种感染的风险。
我们报告了一例由念珠菌引起的自发性糖尿病 Torii 大鼠（非肥胖型糖尿病模型）的肉芽肿性心肌炎。
一只 61 周龄的雄性 SDT 大鼠，在常规环境中饲养。大鼠提供商业饮食和自来水自由摄取。采集心脏并准备苏木精-伊红、天狼星红、吉姆萨、Grocott 染色的标本。组织学上，在左心室壁观察到大肉芽组织的形成。病灶的中心显示坏死。此外，病灶周围和心肌细胞之间的炎症细胞浸润和纤维成分增加。病灶中偶尔出现的 Grocott 和吉姆萨染色阳性细胞团块被认为是念珠菌，因为它们具有特征性的形态。
心肌炎的发生和进展可能与糖尿病引起的代偿状态有关。
