Rajamanuri Medha, Garg Meher, Siddiqui Harris, Pannala Sreeram
Southern Illinois University-School of Medicine, Springfield, IL.
Springfield High School, Springfield, IL.
ACG Case Rep J. 2024 Apr 1;11(4):e01313. doi: 10.14309/crj.0000000000001313. eCollection 2024 Apr.
Ischemic colitis (IC) occurs when there is a temporary lack of adequate blood supply to the intestines, particularly in vulnerable areas such as the splenic flexure and sigmoid colon, which lack sufficient collateral blood vessels. Although primarily seen in older individuals with atherosclerotic risk factors, IC can also be triggered by hormonal contraceptives in young women. Although estrogen-containing oral contraceptives are known to increase thromboembolic risk, the impact of progesterone is not well understood. We report a unique case of biopsy-confirmed IC in a previously healthy 30-year-old woman who presented with abdominal pain and bloody diarrhea 2 months after initiation of progesterone-only oral contraceptive. This occurrence, although rare, underscores the need for further research on the impact of progesterone on coagulation, especially concerning mesenteric arteries.
缺血性结肠炎（IC）是指肠道暂时缺乏充足血液供应时发生的病症，特别是在脾曲和乙状结肠等缺乏足够侧支血管的易损区域。虽然IC主要见于有动脉粥样硬化风险因素的老年人，但年轻女性使用激素避孕药也可能引发。虽然含雌激素的口服避孕药已知会增加血栓栓塞风险，但孕酮的影响尚不清楚。我们报告了一例独特病例，一名30岁既往健康的女性在开始使用仅含孕酮的口服避孕药2个月后出现腹痛和血性腹泻，经活检确诊为IC。这种情况虽然罕见，但凸显了进一步研究孕酮对凝血的影响的必要性，特别是关于肠系膜动脉方面。
