延长培养时间对单胚胎或双胚胎玻璃化冷冻复苏后出生的单胎新生儿出生体重的影响。
The effect of an extended culture period on birth weight among singletons born after single or double vitrified embryo transfer.
机构信息
Department of Assisted Reproduction, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Department of Assisted Reproduction, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
出版信息
Front Endocrinol (Lausanne). 2024 Mar 19;15:1184966. doi: 10.3389/fendo.2024.1184966. eCollection 2024.
AIM
To evaluate the effect of an extended culture period on birth weight among singletons born after vitrified-warmed embryo transfer.
METHODS
A retrospective cohort study was performed among 12400 women who gave birth to 1015, 1027, 687, and 9671 singletons after single blastocyst transfer, single cleavage-stage embryo transfer, double blastocyst transfer, and double cleavage-stage embryo transfer, respectively.
RESULTS
The unadjusted birth weight of singletons born after vitrified blastocyst transfer were heavier than those born after cleavage-stage transfer (β=30.28, SE=13.17, P=0.022), as were the adjusted birth weights (β=0.09, SE=0.03, P=0.007). In addition, there was a 37% increased odd of having an infant with high birth weight after vitrified blastocyst transfer compared with vitrified cleavage stage transfer (OR=1.37, 95% CI:1.07-1.77).
CONCLUSION
The unadjusted and adjusted birth weight and odds of having an infant with high birth weight significantly increased after blastocyst transfer compared with cleavage-stage embryo transfer in vitrified-warmed cycles.
目的
评估延长培养期对玻璃化冻融胚胎移植后单胎出生体重的影响。
方法
对分别接受单囊胚移植、卵裂期胚胎移植、双囊胚移植和双卵裂期胚胎移植后分娩的 12400 名妇女所生的 1015、1027、687 和 9671 名单胎进行回顾性队列研究。
结果
未校正的玻璃化冻融囊胚移植后单胎出生体重高于卵裂期胚胎移植后单胎出生体重（β=30.28，SE=13.17，P=0.022），校正后出生体重也是如此（β=0.09，SE=0.03，P=0.007）。此外，与玻璃化冻融卵裂期胚胎移植相比，玻璃化冻融囊胚移植后婴儿出生体重高的几率增加了 37%（OR=1.37，95%CI：1.07-1.77）。
结论
与卵裂期胚胎移植相比，玻璃化冻融胚胎移植后未校正和校正的出生体重以及出生体重高的婴儿几率显著增加。
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