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瘦素/体重指数比值是否可作为子宫内膜异位症的可靠生物标志物？

Is the leptin/BMI ratio a reliable biomarker for endometriosis?

机构信息

OVIklinika Infertility Center, Warsaw, Poland.

Bioanalysis Laboratory, Faculty of Chemistry, University of Bialystok, Bialystok, Poland.

出版信息

Front Endocrinol (Lausanne). 2024 Mar 19;15:1359182. doi: 10.3389/fendo.2024.1359182. eCollection 2024.

DOI:
10.3389/fendo.2024.1359182
PMID:38567305
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10985179/
Abstract

BACKGROUND

The aim of this study was to analyze the concentration of leptin in peritoneal fluid and plasma and to assess their role as potential biomarkers in the diagnosis of endometriosis.

MATERIALS & METHODS: Leptin adjusted for BMI (leptin/BMI ratio) was measured using surface plasmon resonance imaging (SPRI) biosensors. Patients with suspected endometriosis were included in the study. Plasma was collected from 70 cases, and peritoneal fluid from 67 cases. Based on the presence of endometriosis lesions detected during laparoscopy, patients were divided into a study group and a control group (patients without endometriosis).

RESULTS

Leptin/BMI ratio in plasma did not differ between women with endometriosis and the control group (0.7159 ± 0.259 vs 0.6992 ± 0.273, p= 0,7988). No significant differences were observed in peritoneal leptin/BMI ratio levels in patients with and without endometriosis (0.6206 ± 0.258 vs 0.6215 ± 0.264, p= 0,9896). Plasma and peritoneal leptin/BMI ratios were significantly lower in women with endometriosis - related primary infertility compared to women with endometriosis without primary infertility (0.640 ± 0.502 vs 0.878 ± 0.623, p < 0.05). The difference was observed in case of primary infertility, but not in terms of the secondary one. No significant differences were noted between leptin/BMI ratio in the proliferative phase and the secretory phase (0.716 ± 0.252 vs 0.697 ± 0.288, p= 0,7785).

CONCLUSION

The results of present study do not support the relevance of leptin concentration determination as a biomarker of the endometriosis. Due to the limited number of samples in the tested group, further studies are needed to confirm its role.

摘要

背景

本研究旨在分析腹腔液和血浆中瘦素的浓度，并评估其作为诊断子宫内膜异位症的潜在生物标志物的作用。

材料与方法

采用表面等离子体共振成像（SPRI）生物传感器检测瘦素/体重指数（leptin/BMI 比值）。纳入疑似子宫内膜异位症的患者。采集 70 例患者的血浆，采集 67 例患者的腹腔液。根据腹腔镜检查中发现的子宫内膜异位症病变，将患者分为研究组和对照组（无子宫内膜异位症患者）。

结果

子宫内膜异位症患者与对照组患者的血浆 leptin/BMI 比值无差异（0.7159 ± 0.259 vs 0.6992 ± 0.273，p=0.7988）。有和无子宫内膜异位症患者的腹腔液 leptin/BMI 比值水平无显著差异（0.6206 ± 0.258 vs 0.6215 ± 0.264，p=0.9896）。与无原发性不孕的子宫内膜异位症患者相比，原发性不孕相关子宫内膜异位症患者的血浆和腹腔液 leptin/BMI 比值显著降低（0.640 ± 0.502 vs 0.878 ± 0.623，p<0.05）。这种差异仅见于原发性不孕，而在继发性不孕中则无。增殖期和分泌期的 leptin/BMI 比值无显著差异（0.716 ± 0.252 vs 0.697 ± 0.288，p=0.7785）。

结论

本研究结果不支持将瘦素浓度测定作为子宫内膜异位症的生物标志物。由于测试组样本数量有限，需要进一步研究来确认其作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772f/10985179/f883c6cfbb47/fendo-15-1359182-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772f/10985179/b78a67612c69/fendo-15-1359182-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772f/10985179/d3333646fd42/fendo-15-1359182-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772f/10985179/0946471236b5/fendo-15-1359182-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772f/10985179/6bfc7d81ebda/fendo-15-1359182-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772f/10985179/e7ad9626e0c5/fendo-15-1359182-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772f/10985179/5f2d94708cc8/fendo-15-1359182-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772f/10985179/f883c6cfbb47/fendo-15-1359182-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772f/10985179/b78a67612c69/fendo-15-1359182-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772f/10985179/d3333646fd42/fendo-15-1359182-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772f/10985179/0946471236b5/fendo-15-1359182-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772f/10985179/6bfc7d81ebda/fendo-15-1359182-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772f/10985179/e7ad9626e0c5/fendo-15-1359182-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772f/10985179/5f2d94708cc8/fendo-15-1359182-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772f/10985179/f883c6cfbb47/fendo-15-1359182-g008.jpg

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