子宫内膜异位症患者血浆和腹膜中多聚（ADP - 核糖）聚合酶水平
Plasma and Peritoneal Poly (ADP-Ribose) Polymerase Levels in Patients with Endometriosis.
作者信息
Kacperczyk-Bartnik Joanna, Bartnik Paweł, Goławski Ksawery, Sierdziński Janusz, Mańka Grzegorz, Kiecka Mariusz, Lipa Michał, Warzecha Damian, Spaczyński Robert, Piekarski Piotr, Banaszewska Beata, Jakimiuk Artur, Issat Tadeusz, Rokita Wojciech, Młodawski Jakub, Szubert Maria, Sieroszewski Piotr, Raba Grzegorz, Szczupak Kamil, Kluz Tomasz, Kluza Marek, Czajkowski Krzysztof, Wielgoś Mirosław, Koc-Żórawska Ewa, Żórawski Marcin, Laudański Piotr
机构信息
II Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-091 Warsaw, Poland.
Club 35, Polish Society of Gynecologists and Obstetricians, 53-125 Wrocław, Poland.
出版信息
Biomedicines. 2022 Oct 1;10(10):2451. doi: 10.3390/biomedicines10102451.
The evidence of poly (ADP-ribose) polymerase (PARP) association with the immune response could be coherent with the immunological theory of endometriosis and suggests the possibility of a new research direction. The aim of the study was to evaluate the levels of PARP in plasma and peritoneal fluid of patients with and without endometriosis. It was a multicenter, cross-sectional study. Plasma and peritoneal fluid samples were collected from patients with and without endometriosis during planned laparoscopic procedures in eight clinical centers. In total, 84 samples of plasma and 84 samples of the peritoneal fluid were included in the final analyses. Double-antibody sandwich enzyme-linked immunosorbent assay was performed in order to assess levels of PARP in collected samples. No statistically significant differences regarding the detected levels of PARP in plasma and peritoneal fluid comparing patients with and without endometriosis were observed. Patients with a history of infertility had significantly higher plasma PARP concentrations ( = 0.04). We have not observed the potential role of PARP concentration levels in plasma nor peritoneal fluid as an endometriosis biomarker. We have determined an association between a higher plasma PARP concentration and a history of infertility.
聚（ADP - 核糖）聚合酶（PARP）与免疫反应相关的证据可能与子宫内膜异位症的免疫学理论相一致，并提示了一个新的研究方向的可能性。本研究的目的是评估有和没有子宫内膜异位症患者血浆和腹腔液中PARP的水平。这是一项多中心横断面研究。在八个临床中心对有和没有子宫内膜异位症的患者在计划的腹腔镜手术期间采集血浆和腹腔液样本。最终分析共纳入84份血浆样本和84份腹腔液样本。采用双抗体夹心酶联免疫吸附测定法评估采集样本中PARP的水平。比较有和没有子宫内膜异位症的患者，未观察到血浆和腹腔液中检测到的PARP水平有统计学显著差异。有不孕史的患者血浆PARP浓度显著更高（=0.04）。我们未观察到血浆或腹腔液中PARP浓度水平作为子宫内膜异位症生物标志物的潜在作用。我们确定了较高的血浆PARP浓度与不孕史之间的关联。
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