β型转化生长因子分泌增加伴随着细胞的病毒转化。
Increased secretion of type beta transforming growth factor accompanies viral transformation of cells.
作者信息
Anzano M A, Roberts A B, De Larco J E, Wakefield L M, Assoian R K, Roche N S, Smith J M, Lazarus J E, Sporn M B
出版信息
Mol Cell Biol. 1985 Jan;5(1):242-7. doi: 10.1128/mcb.5.1.242-247.1985.
Abstract
Cells transformed by Harvey or Moloney sarcoma virus secrete at least 40 times as much type beta transforming growth factor as their respective untransformed control cells. The transformed cells bind only 20 to 50% as much type beta transforming growth factor as the control cells, suggesting that transformation causes down-regulation of the type beta transforming growth factor receptor.
摘要
被哈维或莫洛尼肉瘤病毒转化的细胞分泌的β型转化生长因子至少是其各自未转化对照细胞的40倍。转化细胞结合的β型转化生长因子仅为对照细胞的20%至50%，这表明转化导致β型转化生长因子受体下调。
相似文献
1
Increased secretion of type beta transforming growth factor accompanies viral transformation of cells.β型转化生长因子分泌增加伴随着细胞的病毒转化。
Mol Cell Biol. 1985 Jan;5(1):242-7. doi: 10.1128/mcb.5.1.242-247.1985.
2
Increased expression of growth factor mRNAs accompanies viral transformation of rodent cells.生长因子信使核糖核酸的表达增加伴随着啮齿动物细胞的病毒转化。
Oncogene Res. 1988;2(2):135-48.
3
Sarcoma growth factor from mouse sarcoma virus-transformed cells. Purification by binding and elution from epidermal growth factor receptor-rich cells.
J Biol Chem. 1980 Apr 25;255(8):3685-90.
4
Transforming growth factors released from Kirsten sarcoma virus transformed cells do not compete for epidermal growth factor membrane receptors.从柯斯顿肉瘤病毒转化细胞中释放的转化生长因子不与表皮生长因子膜受体竞争。
J Cell Physiol. 1983 Oct;117(1):116-22. doi: 10.1002/jcp.1041170116.
5
Sarcoma growth factor from conditioned medium of virally transformed cells is composed of both type alpha and type beta transforming growth factors.病毒转化细胞条件培养基中的肉瘤生长因子由α型和β型转化生长因子组成。
Proc Natl Acad Sci U S A. 1983 Oct;80(20):6264-8. doi: 10.1073/pnas.80.20.6264.
6
Monoclonal antibody detection of transformation associated protein (TAP) in ts110 Moloney murine sarcoma virus transformed 6M2 cells that are different from the mos gene product.在ts110莫洛尼鼠肉瘤病毒转化的6M2细胞中，对不同于mos基因产物的转化相关蛋白（TAP）进行单克隆抗体检测。
Biochem Biophys Res Commun. 1986 Feb 13;134(3):1223-30. doi: 10.1016/0006-291x(86)90381-5.
7
Cell-mediated co-action of transforming growth factors: incubation of type beta with normal rat kidney cells produces a soluble activity that prolongs the ruffling response to type alpha.转化生长因子的细胞介导协同作用：β型转化生长因子与正常大鼠肾细胞孵育产生一种可溶性活性物质，可延长对α型转化生长因子的皱襞反应。
J Cell Biol. 1986 Apr;102(4):1230-4. doi: 10.1083/jcb.102.4.1230.
8
An assay for type-beta transforming growth factor receptor.
Methods Enzymol. 1987;146:167-73. doi: 10.1016/s0076-6879(87)46019-9.
9
Bifunctional activity of transforming growth factor type beta on the growth of NRK-49F cells, normal and transformed by Kirsten murine sarcoma virus.转化生长因子β对经 Kirsten 小鼠肉瘤病毒转化的正常 NRK-49F 细胞生长的双功能活性。
J Cell Physiol. 1988 Jul;136(1):175-81. doi: 10.1002/jcp.1041360123.
10
Identification of receptors for type-beta transforming growth factor.β型转化生长因子受体的鉴定
Methods Enzymol. 1987;146:174-95. doi: 10.1016/s0076-6879(87)46020-5.
引用本文的文献
1
Chemotherapeutic Targeting of the Transforming Growth Factor-β Pathway in Breast Cancers.乳腺癌中转化生长因子-β通路的化疗靶向治疗
Breast Cancer Manag. 2014;3(1):73-85. doi: 10.2217/bmt.13.74.
2
Erythrocyte NADPH oxidase activity modulated by Rac GTPases, PKC, and plasma cytokines contributes to oxidative stress in sickle cell disease.红细胞 NADPH 氧化酶活性受 Rac GTPases、PKC 和血浆细胞因子调节，导致镰状细胞病中的氧化应激。
Blood. 2013 Mar 14;121(11):2099-107. doi: 10.1182/blood-2012-07-441188. Epub 2013 Jan 24.
3
Deconstructing the mechanisms and consequences of TGF-β-induced EMT during cancer progression.剖析 TGF-β 诱导的 EMT 在癌症进展过程中的机制和后果。
Cell Tissue Res. 2012 Jan;347(1):85-101. doi: 10.1007/s00441-011-1199-1. Epub 2011 Jun 21.
4
Transforming growth factor-beta can suppress tumorigenesis through effects on the putative cancer stem or early progenitor cell and committed progeny in a breast cancer xenograft model.在乳腺癌异种移植模型中，转化生长因子-β可通过对假定的癌症干细胞或早期祖细胞及其分化后代的作用来抑制肿瘤发生。
Cancer Res. 2007 Sep 15;67(18):8643-52. doi: 10.1158/0008-5472.CAN-07-0982.
5
Restoration of Smad4 in BxPC3 pancreatic cancer cells attenuates proliferation without altering angiogenesis.在BxPC3胰腺癌细胞中恢复Smad4可减弱增殖，而不改变血管生成。
Clin Exp Metastasis. 2005;22(6):461-73. doi: 10.1007/s10585-005-2891-x.
6
Transforming growth factor beta1 (TGF-beta1) is a preoperative prognostic indicator in advanced gastric carcinoma.转化生长因子β1（TGF-β1）是进展期胃癌的术前预后指标。
Br J Cancer. 1998 Nov;78(10):1373-8. doi: 10.1038/bjc.1998.687.
7
Oncogenes as inducers of tumor angiogenesis.作为肿瘤血管生成诱导剂的癌基因。
Cancer Metastasis Rev. 1995 Dec;14(4):263-77. doi: 10.1007/BF00690598.
8
Sequential changes in MHC antigen expression induced by the v-Ki-ras oncogene.由v-Ki-ras癌基因诱导的MHC抗原表达的顺序变化。
Cancer Immunol Immunother. 1993 Nov;37(6):361-6. doi: 10.1007/BF01526791.
9
Regulation of adhesion and growth of fibrosarcoma cells by NF-kappa B RelA involves transforming growth factor beta.NF-κB RelA对纤维肉瘤细胞黏附和生长的调节涉及转化生长因子β。
Mol Cell Biol. 1994 Aug;14(8):5326-32. doi: 10.1128/mcb.14.8.5326-5332.1994.
10
TGF-beta 1 stimulation of cell locomotion utilizes the hyaluronan receptor RHAMM and hyaluronan.转化生长因子β1对细胞运动的刺激作用利用了透明质酸受体RHAMM和透明质酸。
J Cell Biol. 1993 Nov;123(3):749-58. doi: 10.1083/jcb.123.3.749.
本文引用的文献
1
THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.高比放射性碘-131标记人生长激素的制备
Biochem J. 1963 Oct;89(1):114-23. doi: 10.1042/bj0890114.
2
Autocrine secretion and malignant transformation of cells.细胞的自分泌分泌与恶性转化。
N Engl J Med. 1980 Oct 9;303(15):878-80. doi: 10.1056/NEJM198010093031511.
3
New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues.由表皮生长因子增强的新型转化生长因子：从非肿瘤组织中分离得到。
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5339-43. doi: 10.1073/pnas.78.9.5339.
4
Serum contains a platelet-derived transforming growth factor.血清中含有一种血小板衍生的转化生长因子。
Proc Natl Acad Sci U S A. 1982 Sep;79(17):5312-6. doi: 10.1073/pnas.79.17.5312.
5
Transforming growth factor(s) production enables cells to grow in the absence of serum: an autocrine system.转化生长因子的产生使细胞能够在无血清条件下生长：一种自分泌系统。
Proc Natl Acad Sci U S A. 1982 Jan;79(2):485-9. doi: 10.1073/pnas.79.2.485.
6
7
Sarcoma growth factor from conditioned medium of virally transformed cells is composed of both type alpha and type beta transforming growth factors.病毒转化细胞条件培养基中的肉瘤生长因子由α型和β型转化生长因子组成。
Proc Natl Acad Sci U S A. 1983 Oct;80(20):6264-8. doi: 10.1073/pnas.80.20.6264.
8
Purification and initial characterization of a type beta transforming growth factor from human placenta.从人胎盘中纯化并初步鉴定一种β型转化生长因子。
Proc Natl Acad Sci U S A. 1983 Jun;80(12):3676-80. doi: 10.1073/pnas.80.12.3676.
9
Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.人类血小板中的转化生长因子-β。主要储存部位的鉴定、纯化及特性分析。
J Biol Chem. 1983 Jun 10;258(11):7155-60.
10
Cellular transformation by coordinated action of three peptide growth factors from human platelets.人类血小板中三种肽生长因子协同作用导致的细胞转化
Nature. 1984;309(5971):804-6. doi: 10.1038/309804a0.
Zotero 插件