β型转化生长因子分泌增加伴随着细胞的病毒转化。
Increased secretion of type beta transforming growth factor accompanies viral transformation of cells.
作者信息
Anzano M A, Roberts A B, De Larco J E, Wakefield L M, Assoian R K, Roche N S, Smith J M, Lazarus J E, Sporn M B
出版信息
Mol Cell Biol. 1985 Jan;5(1):242-7. doi: 10.1128/mcb.5.1.242-247.1985.
Abstract
Cells transformed by Harvey or Moloney sarcoma virus secrete at least 40 times as much type beta transforming growth factor as their respective untransformed control cells. The transformed cells bind only 20 to 50% as much type beta transforming growth factor as the control cells, suggesting that transformation causes down-regulation of the type beta transforming growth factor receptor.
摘要
被哈维或莫洛尼肉瘤病毒转化的细胞分泌的β型转化生长因子至少是其各自未转化对照细胞的40倍。转化细胞结合的β型转化生长因子仅为对照细胞的20%至50%，这表明转化导致β型转化生长因子受体下调。
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本文引用的文献
1
THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.高比放射性碘-131标记人生长激素的制备
Biochem J. 1963 Oct;89(1):114-23. doi: 10.1042/bj0890114.
2
Autocrine secretion and malignant transformation of cells.细胞的自分泌分泌与恶性转化。
N Engl J Med. 1980 Oct 9;303(15):878-80. doi: 10.1056/NEJM198010093031511.
3
New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues.由表皮生长因子增强的新型转化生长因子：从非肿瘤组织中分离得到。
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5339-43. doi: 10.1073/pnas.78.9.5339.
4
Serum contains a platelet-derived transforming growth factor.血清中含有一种血小板衍生的转化生长因子。
Proc Natl Acad Sci U S A. 1982 Sep;79(17):5312-6. doi: 10.1073/pnas.79.17.5312.
5
Transforming growth factor(s) production enables cells to grow in the absence of serum: an autocrine system.转化生长因子的产生使细胞能够在无血清条件下生长：一种自分泌系统。
Proc Natl Acad Sci U S A. 1982 Jan;79(2):485-9. doi: 10.1073/pnas.79.2.485.
6
7
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8
Purification and initial characterization of a type beta transforming growth factor from human placenta.从人胎盘中纯化并初步鉴定一种β型转化生长因子。
Proc Natl Acad Sci U S A. 1983 Jun;80(12):3676-80. doi: 10.1073/pnas.80.12.3676.
9
Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.人类血小板中的转化生长因子-β。主要储存部位的鉴定、纯化及特性分析。
J Biol Chem. 1983 Jun 10;258(11):7155-60.
10
Cellular transformation by coordinated action of three peptide growth factors from human platelets.人类血小板中三种肽生长因子协同作用导致的细胞转化
Nature. 1984;309(5971):804-6. doi: 10.1038/309804a0.
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