Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China.
Department of Neurology, the Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Psychogeriatrics. 2024 Jul;24(4):802-810. doi: 10.1111/psyg.13122. Epub 2024 Apr 3.
Most studies have focused on comparing blood lipid biomarkers between Parkinson's disease (PD) and normal controls (NC). However, further research is necessary to explore the impact of blood lipid levels on motor and cognitive function, as well as the progression of motor dysfunction and cognitive decline over time. Thus, the aim of this study is to investigate the relationship between blood lipid biomarkers and these indicators in individuals with PD.
The cohort study enrolled 157 PD patients and 146 NC from the Tianjin Huanhu Hospital from September 2017 to September 2019. Serum lipid fractions were detected in fasting serum samples. PD patients were followed up at 2 ± 0.6 years for clinical assessment.
PD patients exhibited lower serum triglyceride (TG) levels as compared to NC (P = 0.008). PD male patients exhibited lower serum lipoprotein cholesterol(LDL-C) and total cholesterol (TC) levels than female patients (LDL-C: P = 0.034; TC: P = 0.019). Serum TG levels correlated significantly with Unified PD Rating Scale III, Hoehn and Yahr stage and Montreal Cognitive Assessment scores in PD patients. Additionally, serum TG levels were associated with follow-up motor function decline and cognitive decline in adjusted regression models in PD patients.
To summarise, the study findings suggest that decreased serum TG levels are significantly associated with greater motor dysfunction, cognitive dysfunction and the greater deterioration of the two indicators.
大多数研究都集中在比较帕金森病（PD）患者和正常对照组（NC）的血脂生物标志物。然而，需要进一步研究来探讨血脂水平对运动和认知功能的影响，以及运动功能障碍和认知能力随时间下降的进展。因此，本研究旨在探讨血脂生物标志物与 PD 患者这些指标之间的关系。
这项队列研究于 2017 年 9 月至 2019 年 9 月期间在天津市环湖医院纳入了 157 名 PD 患者和 146 名 NC。在空腹血清样本中检测血清脂质成分。PD 患者在 2 ± 0.6 年时进行临床评估随访。
与 NC 相比，PD 患者的血清甘油三酯（TG）水平较低（P = 0.008）。PD 男性患者的血清脂蛋白胆固醇（LDL-C）和总胆固醇（TC）水平低于女性患者（LDL-C：P = 0.034；TC：P = 0.019）。PD 患者的血清 TG 水平与统一帕金森病评定量表 III、Hoehn 和 Yahr 分期以及蒙特利尔认知评估评分显著相关。此外，在 PD 患者的调整回归模型中，血清 TG 水平与随访期间的运动功能下降和认知下降相关。
总之，研究结果表明，血清 TG 水平降低与更大的运动功能障碍、认知功能障碍以及这两个指标的更大恶化显著相关。
