Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, MC 8849, Dallas, Texas, 75390, United States.
Department of Radiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, 75390, United States.
Brain Imaging Behav. 2024 Aug;18(4):884-891. doi: 10.1007/s11682-024-00879-6. Epub 2024 Apr 3.
Most prior studies have reported decreased amygdala volume in those with a history of alcohol use disorder. Decreased amygdala volume associated with alcohol use disorder may be related to an increased risk of addiction and relapse. However, the relationship between amygdala volume and a broad range of alcohol consumption is largely unexplored. The present cross-sectional analysis investigates the relationship between amygdala volume and self-reported alcohol consumption in participants of the Dallas Heart Study, a community-based study of Dallas County, Texas residents. Brain imaging and survey data from participants (n = 2023) were obtained, and multiple linear regressions were performed with the average amygdala volume as the dependent variable and drinking status, drinking risk, drinks per week, and binge drinking as independent variables. Drinking risk was categorized such that low-risk constituted ≤ 14 drinks per week in men and ≤ 7 drinks per week in women, while > 14 drinks per week in men and > 7 drinks per week in women constituted high-risk. Age, sex, intracranial volume, body mass index, education, and Quick Inventory of Depressive Symptomatology-Self Report score were included in all models as covariates. No statistically significant (p ≤ .05) associations were observed between self-reported alcohol consumption and amygdala volume. The present study suggests non-significant relationships between self-reported alcohol consumption and amygdala volume when controlling for relevant demographic factors in a large, community-based sample.
大多数先前的研究报告表明，有酗酒史的人的杏仁核体积减小。与酒精使用障碍相关的杏仁核体积减小可能与成瘾和复发的风险增加有关。然而，杏仁核体积与广泛的酒精摄入量之间的关系在很大程度上尚未得到探索。本横断面分析调查了德克萨斯州达拉斯县社区为基础的达拉斯心脏研究参与者的杏仁核体积与自我报告的酒精摄入量之间的关系。获得了参与者的脑成像和调查数据（n=2023），并使用平均杏仁核体积作为因变量，饮酒状态、饮酒风险、每周饮酒量和 binge drinking 作为自变量进行多元线性回归。饮酒风险的分类为：男性每周饮酒量≤14 杯且女性每周饮酒量≤7 杯为低风险，男性每周饮酒量>14 杯且女性每周饮酒量>7 杯为高风险。所有模型均将年龄、性别、颅内体积、体重指数、教育程度和贝克抑郁自评量表得分作为协变量。在一个大型的社区样本中，当控制相关人口统计学因素时，自我报告的酒精摄入量与杏仁核体积之间没有观察到统计学上显著的（p≤.05）关联。本研究表明，在控制相关人口统计学因素的情况下，自我报告的酒精摄入量与杏仁核体积之间存在非显著关系。
