Department of Neurology, Baylor College of Medicine, 7200 Cambridge Street, 9th Floor, MS: BCM609, Houston, TX 77030, USA.
Department of Neurology, Parkinson's Disease Center and Movement Disorders Clinic, Baylor College of Medicine, 7200 Cambridge Street, 9th Floor, MS:BCM609, Houston, TX 77030, USA.
Clin Liver Dis. 2019 Feb;23(1):141-155. doi: 10.1016/j.cld.2018.09.010.
Chronic alcohol use induces silent changes in the structure and function of the central and peripheral nervous systems that eventually result in irreversible, debilitating repercussions. Once identified, nutritional supplementation and cessation measures are critical in preventing further neurologic damage. The proposed mechanisms of neuronal injury in chronic alcohol abuse include direct toxic effects of alcohol and indirect effects, including those resulting from hepatic dysfunction, nutritional deficiencies, and neuroinflammation. Clinical manifestations include cerebellar ataxia, peripheral neuropathy and Wernicke-Korsakoff encephalopathy. Continued exploration of the pathophysiologic mechanisms may lead to the discovery of early interventions that can prevent permanent neurologic injury.
慢性酒精使用会导致中枢和外周神经系统的结构和功能发生无声的变化，最终导致不可逆转的、使人虚弱的后果。一旦确定，营养补充和停止措施对于防止进一步的神经损伤至关重要。慢性酒精滥用中神经元损伤的提出机制包括酒精的直接毒性作用和间接作用，包括肝功能障碍、营养缺乏和神经炎症引起的作用。临床表现包括小脑共济失调、周围神经病和 Wernicke-Korsakoff 脑病。对病理生理机制的持续探索可能会导致发现早期干预措施，从而预防永久性神经损伤。
