Department of Emergency Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Department of Emergency Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Biomed Pharmacother. 2024 May;174:116502. doi: 10.1016/j.biopha.2024.116502. Epub 2024 Apr 3.
Acute kidney injury (AKI) is a common clinical syndrome characterized by a rapid deterioration in renal function, manifested by a significant increase in creatinine and a sharp decrease in urine output. The incidence of morbidity and mortality associated with AKI is on the rise, with most patients progressing to chronic kidney disease or end-stage renal disease. Treatment options for patients with AKI remain limited. Circular RNA (circRNA) is a wide and diverse class of non-coding RNAs that are present in a variety of organisms and are involved in gene expression regulation. Studies have shown that circRNA acts as a competing RNA, is involved in disease occurrence and development, and has potential as a disease diagnostic and prognostic marker. CircRNA is involved in the regulation of important biological processes, including apoptosis, oxidative stress, and inflammation. This study reviews the current status and progress of circRNA research in the context of AKI.
急性肾损伤（AKI）是一种常见的临床综合征，其特征为肾功能迅速恶化，表现为肌酐显著升高和尿量急剧减少。与 AKI 相关的发病率和死亡率呈上升趋势，大多数患者进展为慢性肾脏病或终末期肾病。AKI 患者的治疗选择仍然有限。环状 RNA（circRNA）是一类广泛而多样的非编码 RNA，存在于多种生物体中，参与基因表达调控。研究表明，circRNA 作为竞争性 RNA，参与疾病的发生发展，具有作为疾病诊断和预后标志物的潜力。circRNA 参与调节重要的生物学过程，包括细胞凋亡、氧化应激和炎症。本研究综述了 AKI 中 circRNA 研究的现状和进展。
