State Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
State Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China; Faculty of Veterinary and Animal Sciences, Department of Animal Breeding and Genetics, The University of Agriculture, Dera Ismail Khan 29220, Pakistan.
Cell Metab. 2024 Apr 2;36(4):725-744. doi: 10.1016/j.cmet.2024.03.004.
Postbiotics, which comprise inanimate microorganisms or their constituents, have recently gained significant attention for their potential health benefits. Extensive research on postbiotics has uncovered many beneficial effects on hosts, including antioxidant activity, immunomodulatory effects, gut microbiota modulation, and enhancement of epithelial barrier function. Although these features resemble those of probiotics, the stability and safety of postbiotics make them an appealing alternative. In this review, we provide a comprehensive summary of the latest research on postbiotics, emphasizing their positive impacts on both human and animal health. As our understanding of the influence of postbiotics on living organisms continues to grow, their application in clinical and nutritional settings, as well as animal husbandry, is expected to expand. Moreover, by substituting postbiotics for antibiotics, we can promote health and productivity while minimizing adverse effects. This alternative approach holds immense potential for improving health outcomes and revolutionizing the food and animal products industries.
后生元,包括无生命的微生物或其成分,最近因其潜在的健康益处而受到广泛关注。后生元对宿主的许多有益作用已被广泛研究,包括抗氧化活性、免疫调节作用、调节肠道微生物群和增强上皮屏障功能。尽管这些特性类似于益生菌,但后生元的稳定性和安全性使它们成为一种有吸引力的替代品。在这篇综述中,我们全面总结了后生元的最新研究,强调了它们对人类和动物健康的积极影响。随着我们对后生元对生物体影响的理解不断加深,它们在临床和营养环境以及畜牧业中的应用预计将扩大。此外,通过用后生元替代抗生素,可以在最小化不良影响的同时促进健康和生产力。这种替代方法具有改善健康结果和彻底改变食品和动物产品行业的巨大潜力。