Zou Zhenzhuang, Fu Li, Liu Jiaying, Huang Bo
Department of Pediatrics, Shenzhen Futian District Maternity & Child Healthcare Hospital, Shenzhen, China.
Department of Pediatrics, The Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai, Guangdong, China.
Clin Respir J. 2025 Aug;19(8):e70118. doi: 10.1111/crj.70118.
Bronchopulmonary dysplasia (BPD) is a chronic lung condition primarily affecting premature infants. It significantly impacts their growth, development, and health. Recently, in vitro models have been created, offering new insights into the causes and potential treatments for BPD. This review summarizes the current methods for creating in vitro models of BPD. It also discusses their evaluation criteria and applications in drug testing and biological research. This paper evaluates the advantages and disadvantages of different models.
支气管肺发育不良（BPD）是一种主要影响早产儿的慢性肺部疾病。它对早产儿的生长、发育和健康有重大影响。最近，已建立了体外模型，为BPD的病因和潜在治疗方法提供了新的见解。本综述总结了目前创建BPD体外模型的方法。还讨论了其评估标准以及在药物测试和生物学研究中的应用。本文评估了不同模型的优缺点。
