Chiesa C, Gianfrilli P, Occhionero M, Luzzi I, Multari G, Werner B, Pacifico L, Midulla M
Clin Pediatr (Phila). 1985 May;24(5):252-5. doi: 10.1177/000992288502400502.
Between December 1982 and November 1983, stool specimens from 15 children with acute lymphoblastic leukemia, who were on maintenance cancer chemotherapy, were examined weekly for the presence of Clostridium difficile and its toxin. Four out of 15 patients were positive for C. difficile: three patients had stool specimens that did not contain toxin, but cultures yielded growth of toxigenic C. difficile on only one occasion. The fourth patient, who had a recent history of hospitalization, particularly aggressive cancer chemotherapy, neutropenia, and antibiotic therapy, excreted both C. difficile and its toxin for at least 1 month. All children were asymptomatic at the time of positive cultures. This preliminary study reveals a low rate of C. difficile colonization in leukemic children on maintenance cancer chemotherapy.
1982年12月至1983年11月期间，对15名正在接受癌症维持化疗的急性淋巴细胞白血病患儿的粪便标本每周进行检查，以检测艰难梭菌及其毒素的存在情况。15名患者中有4名艰难梭菌检测呈阳性：3名患者的粪便标本中未检测到毒素，但培养物仅在一次培养中产生了产毒素艰难梭菌的生长。第四名患者近期有住院史，接受过特别积极的癌症化疗、中性粒细胞减少症治疗和抗生素治疗，排泄艰难梭菌及其毒素至少1个月。所有患儿在培养结果呈阳性时均无症状。这项初步研究显示，正在接受癌症维持化疗的白血病患儿中艰难梭菌定植率较低。
