Heidarzadehpilehrood Roozbeh, Pirhoushiaran Maryam
Department of Obstetrics & Gynaecology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, 1417613151, Iran.
Noncoding RNA Res. 2024 Jan 17;9(2):624-640. doi: 10.1016/j.ncrna.2024.01.002. eCollection 2024 Jun.
Polycystic ovary syndrome (PCOS) is the most common condition affecting women of reproductive age globally. PCOS continues to be the largest contributing factor to female infertility despite significant progress in our knowledge of the molecular underpinnings and treatment of the condition. The fact that PCOS is a very diverse condition makes it one of the key reasons why we haven't been able to overcome it. Non-coding RNAs (ncRNAs) are implicated in the development of PCOS, according to growing evidence. However, it is unclear how the complex regulatory relationships between the many ncRNA types contribute to the growth of this malignancy. Competing endogenous RNA (ceRNA), a recently identified mechanism in the RNA world, suggests regulatory interactions between various RNAs, including long non-coding RNAs (lncRNAs), microRNAs (miRNAs), transcribed pseudogenes, and circular RNAs (circRNAs). Recent studies on PCOS have shown that dysregulation of multiple ceRNA networks (ceRNETs) between these ncRNAs plays crucial roles in developing the defining characteristics of PCOS development. And it is believed that such a finding may open a new door for a deeper comprehension of PCOS's unexplored facets. In addition, it may be able to provide fresh biomarkers and effective therapy targets for PCOS. This review will go over the body of information that exists about the primary roles of ceRNETs before highlighting the developing involvement of several newly found ceRNETs in a number of PCOS characteristics.
多囊卵巢综合征（PCOS）是全球影响育龄女性的最常见病症。尽管我们在该病症的分子基础和治疗方面取得了重大进展，但PCOS仍然是女性不孕的最大促成因素。PCOS是一种非常多样化的病症，这一事实是我们一直无法攻克它的关键原因之一。越来越多的证据表明，非编码RNA（ncRNA）与PCOS的发生有关。然而，尚不清楚多种ncRNA类型之间复杂的调控关系如何促成这种病症的发展。竞争性内源RNA（ceRNA）是RNA世界中最近发现的一种机制，它表明了包括长链非编码RNA（lncRNA）、微小RNA（miRNA）、转录假基因和环状RNA（circRNA）在内的各种RNA之间的调控相互作用。最近关于PCOS的研究表明，这些ncRNA之间多个ceRNA网络（ceRNET）的失调在PCOS发展的特征形成中起着关键作用。并且人们认为，这一发现可能为更深入理解PCOS尚未探索的方面打开一扇新的大门。此外，它或许能够为PCOS提供新的生物标志物和有效的治疗靶点。本综述将梳理有关ceRNET主要作用的现有信息，然后重点介绍一些新发现的ceRNET在多种PCOS特征中不断发展的作用。
