Yang Yuxin, Xiong Yiyi, Pan Zezheng
Jiangxi Medical College, Nanchang University, Nanchang 330006, China.
Biol Reprod. 2023 Mar 13;108(3):363-381. doi: 10.1093/biolre/ioac200.
The molecular mechanism of non-tumor female reproductive diseases is complicated and needs to be further elucidated. Recently, increasing evidence indicates that non-coding RNAs(ncRNAs) which are extremely rich in the female reproductive system are crucial factors in the pathogenesis of some female reproductive disorders. In fact, these ncRNAs such as lncRNAs, circRNAs, snoRNAs, and pseudogenes that share the same miRNA response elements (MREs) with mRNAs could compete for miRNA binding site to regulate gene expression, this phenomenon is known as the competing endogenous RNAs(ceRNAs) mechanism. This review aims to summarize the role of ceRNAs in cell proliferation, apoptosis, migration, and invasion of non-tumor female reproductive diseases such as polycystic ovary syndrome (PCOS), premature ovarian failure (POF), pre-eclampsia (PE), recurrent implantation failure (RIF), recurrent spontaneous abortion (RSA), endometriosis (EM), and endometritis, and list ceRNAs regulatory axes as well as downstream related signaling pathway. Additionally, based on certain ncRNAs that have already been proven to exist at differential levels in patient tissue samples, we also generalize some ncRNAs that can be used as potential biomarkers and therapeutic targets for these diseases in the future.
非肿瘤性女性生殖疾病的分子机制复杂，有待进一步阐明。近来，越来越多的证据表明，在女性生殖系统中极为丰富的非编码RNA（ncRNA）是某些女性生殖疾病发病机制中的关键因素。事实上，这些lncRNA、circRNA、snoRNA和假基因等ncRNA与mRNA共享相同的微小RNA反应元件（MRE），可竞争微小RNA结合位点以调控基因表达，这种现象被称为竞争性内源RNA（ceRNA）机制。本综述旨在总结ceRNA在多囊卵巢综合征（PCOS）、卵巢早衰（POF）、子痫前期（PE）、反复种植失败（RIF）、复发性自然流产（RSA）、子宫内膜异位症（EM）和子宫内膜炎等非肿瘤性女性生殖疾病的细胞增殖、凋亡、迁移和侵袭中的作用，并列出ceRNA调控轴以及下游相关信号通路。此外，基于某些已被证实在患者组织样本中存在差异表达的ncRNA，我们还归纳了一些未来可作为这些疾病潜在生物标志物和治疗靶点的ncRNA。
