Oral fluoroquinolones and the risk of Achilles tendon rupture.

• Using nationwide Danish health register data, associations between fluoroquinolone use and elevated hazard rates of Achilles tendon rupture were found. • Associations were most pronounced with increasing dosage and within 30 days following fluoroquinolone use. • Despite recent findings calling the previously suggested associations between fluoroquinolones and aortic and valvular diseases into question, advised caution in relation to tendinopathies still seems relevant.