1 型糖尿病患者中度糖尿病酮症酸中毒缓解过程中和缓解后的胃排空情况：病例系列研究。
Gastric emptying during and following resolution of moderate diabetic ketoacidosis in type 1 diabetes: a case series.
机构信息
The University of Adelaide Faculty of Health and Medical Sciences, Adelaide, South Australia, Australia.
Mater Hospital Brisbane, Brisbane, Queensland, Australia.
出版信息
BMJ Open Diabetes Res Care. 2024 Apr 3;12(2):e003854. doi: 10.1136/bmjdrc-2023-003854.
INTRODUCTION
To use the 'gold standard' technique of scintigraphy to quantify gastric emptying (GE) as soon as practicable during an admission with diabetic ketoacidosis (DKA) and following its resolution at least 7 days later.
RESEARCH DESIGN AND METHODS
Five patients with type 1 diabetes, age 29±12 years; Body Mass Index 23±3 kg/m; hemoglobin A1c 11.3%±1.9%, were studied during an admission with DKA and following its resolution. Solid and liquid GE were measured using scintigraphy. Solid emptying was assessed via the percentage intragastric retention at 100 min and that of liquid by the 50% emptying time.
RESULTS
There was no difference in either solid or liquid GE at the initial study compared with the follow-up. Median (IQR) solid retention was 47±20 versus 38%±33%, respectively; p=0.31, and time to empty 50% of liquid was 37±25 min versus 35±15 min, p=0.31, at the initial and follow-up GE study, respectively.
CONCLUSIONS
GE of solids and liquids is not affected by moderate DKA, inferring that earlier reintroduction of oral intake may be appropriate.
简介
在患有糖尿病酮症酸中毒（DKA）的住院期间，尽快使用闪烁扫描术这种“金标准”技术来定量胃排空（GE），并在至少 7 天后其恢复后再次进行测量。
研究设计和方法
研究了 5 名年龄在 29±12 岁、体重指数为 23±3kg/m2、糖化血红蛋白为 11.3%±1.9%的 1 型糖尿病患者，他们在患有 DKA 期间和恢复后接受了研究。使用闪烁扫描术测量固体和液体 GE。通过 100 分钟时的胃内残留百分比评估固体排空，通过 50%排空时间评估液体排空。
结果
与随访相比，初始研究中固体或液体 GE 没有差异。固体残留中位数（IQR）分别为 47±20%和 38%±33%；p=0.31，液体排空 50%的时间分别为 37±25 分钟和 35±15 分钟；p=0.31，在初始和随访的 GE 研究中。
结论
中度 DKA 不会影响固体和液体的 GE，这表明可以更早地重新开始口服摄入。
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