Department of Gastroenterology and Hepatology, University Hospital Zurich, Raemistrassse 100, CH-8091 Zurich, Switzerland.
Department of Gastroenterology and Hepatology, University Hospital Zurich, Raemistrassse 100, CH-8091 Zurich, Switzerland.
Immunol Allergy Clin North Am. 2024 May;44(2):185-196. doi: 10.1016/j.iac.2023.12.006. Epub 2024 Jan 11.
Adult patients with eosinophilic esophagitis (EoE) typically present with a history of dysphagia for solids, sometimes with additional reflux-like pain and a history of prior food impactions. In contrast to these alarming symptoms, the general appearance and physical examination of adult patients with EoE is in line with apparently healthy individuals. Therefore, the diagnosis is based on a history of solid-food dysphagia and eosinophilic tissue infiltration. Importantly, the increasing prevalence of EoE variants, that is, typical EoE symptoms in the absence of a relevant eosinophilia, and several studies with eosinophil-targeting drugs, call the pathogenic role of eosinophils into question.
成人嗜酸性食管炎 (EoE) 患者通常表现为固体食物吞咽困难，有时伴有类似反流的疼痛和食物嵌塞史。与这些令人警惕的症状相反，EoE 成人患者的一般外观和体检与明显健康个体一致。因此，诊断基于固体食物吞咽困难和嗜酸性组织浸润的病史。重要的是，EoE 变异型（即典型 EoE 症状而无相关嗜酸性粒细胞增多症）的患病率不断增加，以及几项针对嗜酸性粒细胞的药物研究，对嗜酸性粒细胞的致病作用提出了质疑。
