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用于实现各向同性高对比度超声成像的紧凑型元微分器。

Compact meta-differentiator for achieving isotropically high-contrast ultrasonic imaging.

作者信息

Jia Yurou, Zhang Suying, Zhang Xuan, Long Houyou, Xu Caibin, Bai Yechao, Cheng Ying, Wu Dajian, Deng Mingxi, Qiu Cheng-Wei, Liu Xiaojun

机构信息

Department of Physics, MOE Key Laboratory of Modern Acoustics, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing, 210093, China.

Department of Electrical and Computer Engineering, National University of Singapore, Singapore, 117583, Singapore.

出版信息

Nat Commun. 2024 Apr 5;15(1):2934. doi: 10.1038/s41467-024-47303-7.

DOI:10.1038/s41467-024-47303-7
PMID:38575561
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10995138/
Abstract

Ultrasonic imaging is crucial in the fields of biomedical engineering for its deep penetration capabilities and non-ionizing nature. However, traditional techniques heavily rely on impedance differences within objects, resulting in poor contrast when imaging acoustically transparent targets. Here, we propose a compact spatial differentiator for underwater isotropic edge-enhanced imaging, which enhances the imaging contrast without the need for contrast agents or external physical fields. This design incorporates an amplitude meta-grating for linear transmission along the radial direction, combined with a phase meta-grating that utilizes focus and spiral phases with a first-order topological charge. Through theoretical analysis, numerical simulations, and experimental validation, we substantiate the effectiveness of our technique in distinguishing amplitude objects with isotropic edge enhancements. Importantly, this method also enables the accurate detection of both phase objects and artificial biological models. This breakthrough creates new opportunities for applications in medical diagnosis and nondestructive testing.

摘要

超声成像因其深度穿透能力和非电离特性在生物医学工程领域至关重要。然而,传统技术严重依赖物体内部的阻抗差异,在对声学透明目标成像时对比度较差。在此,我们提出一种用于水下各向同性边缘增强成像的紧凑型空间微分器,它无需造影剂或外部物理场即可增强成像对比度。该设计包含一个用于沿径向线性传输的振幅超光栅,以及一个利用具有一阶拓扑电荷的聚焦和螺旋相位的相位超光栅。通过理论分析、数值模拟和实验验证,我们证实了我们的技术在区分具有各向同性边缘增强的振幅物体方面的有效性。重要的是,该方法还能够准确检测相位物体和人工生物模型。这一突破为医学诊断和无损检测应用创造了新机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e3e/10995138/ea54b74530cd/41467_2024_47303_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e3e/10995138/0c2f619b0647/41467_2024_47303_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e3e/10995138/c782a9f8033f/41467_2024_47303_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e3e/10995138/c877cf94ccf5/41467_2024_47303_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e3e/10995138/58261c2935d9/41467_2024_47303_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e3e/10995138/e0ab5b6bf9a4/41467_2024_47303_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e3e/10995138/ea54b74530cd/41467_2024_47303_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e3e/10995138/0c2f619b0647/41467_2024_47303_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e3e/10995138/c782a9f8033f/41467_2024_47303_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e3e/10995138/c877cf94ccf5/41467_2024_47303_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e3e/10995138/58261c2935d9/41467_2024_47303_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e3e/10995138/e0ab5b6bf9a4/41467_2024_47303_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e3e/10995138/ea54b74530cd/41467_2024_47303_Fig6_HTML.jpg

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本文引用的文献

1
Single-shot isotropic differential interference contrast microscopy.单次各向同性差分干涉对比显微镜。
Nat Commun. 2023 Apr 12;14(1):2063. doi: 10.1038/s41467-023-37606-6.
2
Superiorly Stable Three-Layer Air Microbubbles Generated by Versatile Ethanol-Water Exchange for Contrast-Enhanced Ultrasound Theranostics.通过通用乙醇-水交换产生的用于超声造影治疗诊断的高度稳定三层空气微泡
ACS Nano. 2023 Jan 10;17(1):263-274. doi: 10.1021/acsnano.2c07300. Epub 2022 Nov 10.
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Orbital Angular Momentum Multiplexing in Space-Time Thermoacoustic Metasurfaces.
时空热声超表面中的轨道角动量复用
Adv Mater. 2022 Jul;34(29):e2202026. doi: 10.1002/adma.202202026. Epub 2022 Jun 6.
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Single-layer spatial analog meta-processor for imaging processing.单层空间模拟元处理器,用于成像处理。
Nat Commun. 2022 Apr 21;13(1):2188. doi: 10.1038/s41467-022-29732-4.
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The emerging role of photoacoustic imaging in clinical oncology.光声成像在临床肿瘤学中的新兴作用。
Nat Rev Clin Oncol. 2022 Jun;19(6):365-384. doi: 10.1038/s41571-022-00615-3. Epub 2022 Mar 23.
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Ultracompact meta-imagers for arbitrary all-optical convolution.用于任意全光卷积的超紧凑型元成像器。
Light Sci Appl. 2022 Mar 18;11(1):62. doi: 10.1038/s41377-022-00752-5.
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Performance Evaluation of Ultrasonic Imaging System (Part I).超声成像系统的性能评估(第一部分)
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Topological optical differentiator.拓扑光学微分器
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