用于癌症治疗与诊断的磁性纳米颗粒
Magnetic Nanoparticles in Cancer Therapy and Diagnosis.
作者信息
Farzin Ali, Etesami Seyed Alireza, Quint Jacob, Memic Adnan, Tamayol Ali
机构信息
Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02139, USA.
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Adv Healthc Mater. 2020 May;9(9):e1901058. doi: 10.1002/adhm.201901058. Epub 2020 Mar 20.
There is urgency for the development of nanomaterials that can meet emerging biomedical needs. Magnetic nanoparticles (MNPs) offer high magnetic moments and surface-area-to-volume ratios that make them attractive for hyperthermia therapy of cancer and targeted drug delivery. Additionally, they can function as contrast agents for magnetic resonance imaging (MRI) and can improve the sensitivity of biosensors and diagnostic tools. Recent advancements in nanotechnology have resulted in the realization of the next generation of MNPs suitable for these and other biomedical applications. This review discusses methods utilized for the fabrication and engineering of MNPs. Recent progress in the use of MNPs for hyperthermia therapy, controlling drug release, MRI, and biosensing is also critically reviewed. Finally, challenges in the field and potential opportunities for the use of MNPs toward improving their properties are discussed.
开发能够满足新兴生物医学需求的纳米材料迫在眉睫。磁性纳米颗粒（MNPs）具有高磁矩和表面积与体积比，这使其在癌症热疗和靶向药物递送方面具有吸引力。此外，它们可用作磁共振成像（MRI）的造影剂，并可提高生物传感器和诊断工具的灵敏度。纳米技术的最新进展已促成了适用于这些及其他生物医学应用的下一代MNPs的实现。本文综述了用于MNPs制备和工程化的方法。还对MNPs在热疗、控制药物释放、MRI和生物传感方面的最新进展进行了批判性综述。最后，讨论了该领域的挑战以及利用MNPs改善其性能的潜在机会。
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