Department of Applied Sciences and Biotechnology, Shoolini University, Himachal Pradesh, Solan, India, 173229.
School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, India, 173229.
AAPS PharmSciTech. 2024 Apr 4;25(4):72. doi: 10.1208/s12249-024-02785-y.
Atopic dermatitis is a skin condition characterized by lichenification (thickening and increased skin marking), eczematous lesions, dry skin, itching, and pruritus. Eugenol is an aromatic polyphenolic compound that has attracted the attention of researchers due to its anti-inflammatory, anti-oxidant, and anti-cancer properties. The primary goal of the present study was to develop and evaluate eugenol-loaded transethosomes for the treatment of AD. Eugenol-loaded transethosomes were formulated using the ethanol injection method and subsequently subjected to particle size analysis, zeta potential, entrapment efficiency, deformability index, and HRTEM analysis. Transethosomal gel was prepared by direct-dispersion method by using Carbopol 940. Results showed transethosomes to be lipid bilayer structures with acceptable size, and high entrapment efficiency. Transethosomal formulation showed shear-thinning behavior. Eugenol-loaded transethosomal gel was significantly able to enhance the retention of the drug in the skin. Transethosomal gel was significantly able to reduce Ear thickness, DLC, TLC, and IL-6 levels in mice model of AD. These results indicate that the eugenol-loaded transethosomal gel could be a promising carrier for the topical administration of eugenol for the treatment of AD.
特应性皮炎是一种皮肤疾病，其特征为苔藓样变（增厚和皮肤标记增加）、湿疹样病变、皮肤干燥、瘙痒和瘙痒。丁香酚是一种芳香多酚化合物，由于其具有抗炎、抗氧化和抗癌特性，引起了研究人员的关注。本研究的主要目的是开发和评估载丁香酚的传递体用于治疗 AD。使用乙醇注入法制备载丁香酚的传递体，随后进行粒径分析、zeta 电位、包封效率、变形指数和 HRTEM 分析。通过直接分散法制备卡波姆 940 的传递体凝胶。结果表明传递体为具有可接受大小和高包封效率的脂质双层结构。传递体制剂表现出剪切稀化行为。载丁香酚的传递体凝胶能够显著提高药物在皮肤中的滞留量。载丁香酚的传递体凝胶能够显著降低 AD 小鼠模型的耳厚度、DLC、TLC 和 IL-6 水平。这些结果表明，载丁香酚的传递体凝胶可以作为丁香酚局部给药的一种有前途的载体，用于治疗 AD。
