Encalada Soto Diana
Division of Minimally Invasive Gynecologic Surgery, Department of Obstetrics and Gynecology, University of South Florida, Tampa, FL, USA -
Minerva Obstet Gynecol. 2024 Dec;76(6):564-577. doi: 10.23736/S2724-606X.23.05313-7. Epub 2024 Apr 4.
Endometriosis is a chronic disease that affects millions of women worldwide, causing dysmenorrhea, chronic pain, and infertility, and has a significant impact on the healthcare system. Despite efforts to understand its pathogenesis, endometriosis is a disease with heterogeneous presentations and phenotypes which is manifested in part by the lack of a non-invasive biomarker available for its diagnosis. This review aims to bridge the gap between theory and practice by summarizing the most promising areas of study for developing a reliable biomarker or combination of biomarkers for the non-invasive diagnosis of endometriosis.
We conducted a comprehensive literature search using the electronic databases PubMed and MEDLINE.
This review summarizes the potential biomarkers for endometriosis, including glycoproteins, inflammatory markers, immunologic markers, angiogenic cytokines, micro RNAs and the microbiome. Each of these biomarkers' role in the development and progression of endometriosis, and their diagnostic potential are discussed in detail.
Endometriosis is a complex and underdiagnosed disease with significant health impact. The development of non-invasive biomarkers for its diagnosis would be immensely valuable, and promising research is being done in this area. While no single biomarker has yet emerged as a reliable diagnostic tool, this review highlights the potential of several biomarkers and the importance of continued research in this field. By improving the diagnosis of endometriosis, we can improve the lives of millions of women worldwide.
子宫内膜异位症是一种慢性疾病，影响着全球数百万女性，导致痛经、慢性疼痛和不孕，并对医疗保健系统产生重大影响。尽管人们努力了解其发病机制，但子宫内膜异位症是一种表现形式和表型各异的疾病，部分表现为缺乏可用于诊断的非侵入性生物标志物。本综述旨在通过总结开发用于子宫内膜异位症非侵入性诊断的可靠生物标志物或生物标志物组合的最有前景的研究领域，弥合理论与实践之间的差距。
我们使用电子数据库PubMed和MEDLINE进行了全面的文献检索。
本综述总结了子宫内膜异位症的潜在生物标志物，包括糖蛋白、炎症标志物、免疫标志物、血管生成细胞因子、微小RNA和微生物群。详细讨论了这些生物标志物在子宫内膜异位症发生发展中的作用及其诊断潜力。
子宫内膜异位症是一种复杂且诊断不足的疾病，对健康有重大影响。开发用于其诊断的非侵入性生物标志物将具有巨大价值，并且该领域正在进行有前景的研究。虽然尚未有单一生物标志物成为可靠的诊断工具，但本综述强调了几种生物标志物的潜力以及该领域持续研究的重要性。通过改善子宫内膜异位症的诊断，我们可以改善全球数百万女性的生活。
