孕期中期给母仓鼠注射前列腺素E2后的产前发育情况。

Prenatal hamster development following maternal administration of PGE2 at midterm.

作者信息

Liebgott B, Wiley M J

出版信息

Prostaglandins Leukot Med. 1985 Mar;17(3):309-18. doi: 10.1016/0262-1746(85)90120-9.

Abstract

The effects of PGE2 on embryonic and fetal development were studied in the golden Syrian hamster. Pregnant hamsters were treated on day 8 of gestation with either 0.2, 0.5, 0.75, or 1.0 mg/kg PGE2 delivered I.P. and the near term litters were compared to those of untreated and vehicle treated controls. Fetuses from the treated litters showed significantly higher frequencies of mortality, lower weights, malformations, and missing ossification centres in comparison to control litters. The results demonstrate that PGE2 is teratogenic in the hamster and the developing neural tube and the fetal skeleton are particularly susceptible to the effects of this teratogen.

摘要

在金黄叙利亚仓鼠中研究了前列腺素E2（PGE2）对胚胎和胎儿发育的影响。怀孕的仓鼠在妊娠第8天经腹腔注射0.2、0.5、0.75或1.0mg/kg的PGE2进行处理，将接近足月产的窝仔与未处理和赋形剂处理的对照组窝仔进行比较。与对照窝仔相比，处理组窝仔的胎儿死亡率显著更高、体重更低、出现畸形且骨化中心缺失。结果表明，PGE2在仓鼠中具有致畸性，发育中的神经管和胎儿骨骼对这种致畸剂的影响尤为敏感。