Floss J L, Casteel S W, Johnson G C, Rottinghaus G E, Krause G F
Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri, Columbia.
Mycopathologia. 1994 Oct;128(1):33-8. doi: 10.1007/BF01104276.
The effects of fumonisin on development of Syrian hamster fetuses were studied using fumonisin B1 and B2 extracted from Fusarium moniliforme corn-culture and purified fumonisin B1. A significant increase in litters with fetal deaths occurred with the high doses of purified (18 mg FB1/kg) and culture-extracted (18 mg FB1 plus 4.5 mg FB2) fumonisin. It is concluded that prenatal exposure to fumonisin on days 8 and 9 of gestation is detrimental to fetal hamster survivability but does not induce clinical maternal intoxication at these doses. Equivalent doses of fumonisin B1, whether from culture-extract or pure solution produced similar results.
利用从串珠镰刀菌玉米培养物中提取并纯化的伏马毒素B1和B2，研究了伏马毒素对叙利亚仓鼠胎儿发育的影响。高剂量纯化的伏马毒素B1（18毫克FB1/千克）和从培养物中提取的伏马毒素（18毫克FB1加4.5毫克FB2）导致死胎的窝数显著增加。得出的结论是，在妊娠第8天和第9天产前接触伏马毒素对仓鼠胎儿的生存能力有害，但在这些剂量下不会引起母体临床中毒。无论来自培养物提取物还是纯溶液，等量的伏马毒素B1产生相似的结果。
