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Teratogenic effects of diazepam in the hamster.

作者信息

Shah R M, Donaldson D, Burdett D

出版信息

Can J Physiol Pharmacol. 1979 Jun;57(6):556-61. doi: 10.1139/y79-084.

DOI:10.1139/y79-084
PMID:487263
Abstract

Pregnant hamsters were treated with different doses of oral and intravenous diazepam during the period of organogenesis. Teratogenic effects of diazepam were observed following oral treatment on days 8 and 10 and following intravenous treatment on day 11 of gestation. Types of malformations included cleft palate, exencephaly, limb anomalies, and hemorrhage. A dose-effect relationship was not observed. Comparison with reported literature seems to indicate that diazepam may be a mild teratogen in some species.

摘要

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