Hepatogastroenterology Division, Department of Precision Medicine, University of Campania Luigi Vanvitelli, Naples 80138, Italy.
Pathology Division, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples 80138, Italy.
World J Gastroenterol. 2024 Mar 7;30(9):1132-1142. doi: 10.3748/wjg.v30.i9.1132.
Melanocortin 3 and 5 receptors ( MCR and MCR) belong to the melanocortin family. However, data regarding their role in inflammatory bowel diseases (IBD) are currently unavailable.
This study aims to ascertain their expression profiles in the colonic mucosa of Crohn's disease (CD) and ulcerative colitis (UC), aligning them with IBD disease endoscopic and histologic activity.
Colonic mucosal biopsies from CD/UC patients were sampled, and immunohistochemical analyses were conducted to evaluate the expression of MCR and MCR. Colonic sampling was performed on both traits with endoscopic scores (Mayo endoscopic score and CD endoscopic index of severity) consistent with inflamed mucosa and not consistent with disease activity ( normal appearing mucosa).
In both CD and UC inflamed mucosa, MCR (CD: + 7.7 fold normal mucosa, < 0.01; UC: + 12 fold normal mucosa, < 0.01) and MCR (CD: + 5.5 fold normal mucosa, < 0.01; UC: + 8.1 fold normal mucosa, < 0.01) were significantly more expressed compared to normal mucosa.
MCR and MCR are expressed in the colon of IBD patients. Furthermore, expression may differ according to disease endoscopic activity, with a higher degree of expression in the traits affected by disease activity in both CD and UC, suggesting a potential use of these receptors in IBD pharmacology.
黑素皮质素 3 和 5 受体（MCR 和 MCR）属于黑素皮质素家族。然而，目前尚无关于它们在炎症性肠病（IBD）中的作用的数据。
本研究旨在确定它们在克罗恩病（CD）和溃疡性结肠炎（UC）结肠黏膜中的表达谱，并将其与 IBD 疾病的内镜和组织学活动相匹配。
采集 CD/UC 患者的结肠黏膜活检标本，进行免疫组织化学分析，评估 MCR 和 MCR 的表达。对内镜评分（Mayo 内镜评分和 CD 内镜严重程度指数）一致的具有炎症黏膜且与疾病活动不一致的（正常外观黏膜）结肠进行采样。
在 CD 和 UC 炎症黏膜中，MCR（CD：+7.7 倍正常黏膜，<0.01；UC：+12 倍正常黏膜，<0.01）和 MCR（CD：+5.5 倍正常黏膜，<0.01；UC：+8.1 倍正常黏膜，<0.01）的表达均明显高于正常黏膜。
MCR 和 MCR 在 IBD 患者的结肠中表达。此外，根据疾病内镜活动的不同，表达可能会有所不同，在 CD 和 UC 中，在受疾病活动影响的性状中表达更高，这表明这些受体在 IBD 药理学中有潜在的用途。
