Chronic Disease Research Center, Medical College, Dalian University, Dalian, Liaoning 116622, P.R. China.
Chronic Disease Research Center, Medical College, Dalian University, Dalian, Liaoning 116622, P.R. China.
Mol Med Rep. 2024 Jun;29(6). doi: 10.3892/mmr.2024.13213. Epub 2024 Apr 5.
Hepatitis B X‑interacting protein (HBXIP) is a membrane protein located on the lysosomal surface and encoded by the Lamtor gene. It is expressed by a wide range of tumor types, including breast cancer, esophageal squamous cell carcinoma and hepatocellular carcinoma, and its expression is associated with certain clinicopathological characteristics. In the past decade, research on the oncogenic mechanisms of HBXIP has increased and the function of HBXIP in normal cells has been gradually elucidated. In the present review, the following was discussed: The normal physiological role of the HBXIP carcinogenic mechanism; the clinical significance of high levels of HBXIP expression in different tumors; HBXIP regulation of transcription, post‑transcription and post‑translation processes in tumors; the role of HBXIP in improving the antioxidant capacity of tumor cells; the inhibition of ferroptosis of tumor cells and regulating the metabolic reprogramming of tumor cells; and the role of HBXIP in promoting the malignant progression of tumors. In conclusion, the present review summarized the existing knowledge of HBXIP, established its carcinogenic mechanism and discussed future related research on HBXIP.
乙型肝炎病毒 X 相互作用蛋白 (HBXIP) 是一种位于溶酶体表面的膜蛋白，由 Lamtor 基因编码。它在多种肿瘤类型中表达，包括乳腺癌、食管鳞状细胞癌和肝细胞癌，其表达与某些临床病理特征相关。在过去的十年中，对 HBXIP 致癌机制的研究增加了，并且 HBXIP 在正常细胞中的功能也逐渐阐明。在本综述中，讨论了以下内容：HBXIP 致癌机制的正常生理作用；不同肿瘤中 HBXIP 高表达的临床意义；HBXIP 在肿瘤中转录、转录后和翻译后过程中的调节作用；HBXIP 提高肿瘤细胞抗氧化能力的作用；抑制肿瘤细胞铁死亡和调节肿瘤细胞代谢重编程的作用；以及 HBXIP 在促进肿瘤恶性进展中的作用。总之，本综述总结了目前对 HBXIP 的认识，建立了其致癌机制，并讨论了未来关于 HBXIP 的相关研究。
